Stable and compact zwitterionic polydiacetylene micelles with tumor-targeting properties

被引：38
|
作者：
Theodorou, Ioanna [1 ,2 ]
Anilkumar, Parambath [3 ]
Lelandais, Benoit [1 ,2 ]
Clarisse, Damien [3 ]
Doerflinger, Anaelle [3 ]
Gravel, Edmond [3 ]
Duconge, Frederic [1 ,2 ]
Doris, Eric [3 ]
机构：
[1] CEA, I2BM, Mol Imaging Res Ctr MIRCen, F-92265 Fontenay Aux Roses, France
[2] Univ Paris 11, CNRS, Unite Rech Associee CEA CNRS2210, F-92265 Fontenay Aux Roses, France
[3] CEA, IBITECS, Serv Chim Bioorgan & Marquage, F-91191 Gif Sur Yvette, France
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 80期
关键词：
DIFFUSE OPTICAL TOMOGRAPHY; DRUG-DELIVERY; POLY(ETHYLENE GLYCOL); STEALTH LIPOSOMES; QUANTUM DOTS; NANOPARTICLES; POLY(CARBOXYBETAINE); PHARMACOKINETICS; THERAPEUTICS; NANOCARRIERS;
D O I：
10.1039/c5cc05333a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Compact polymerized polydiacetylene-micelles with "stealth'' zwitterionic surface coating were assembled and tested in a murine xenograft model of breast cancer. In vivo fluorescence imaging indicated accumulation in the tumor area and histological studies revealed predominant uptake of the micelles at the margins of the tumor, thereby allowing the delineation of its volume.
引用
收藏
页码：14937 / 14940
页数：4
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