Synthesis of combretastatin A4 analogues on steroidal framework and their anti-breast cancer activity

被引：33

作者：

Parihar, Swati ^{[1
]}

Kumar, Amit ^{[2
]}

Chaturvedi, Amit K. ^{[1
]}

Sachan, Naresh Kumar ^{[1
]}

Luqman, Suaib ^{[1
]}

Changkija, Bendangla ^{[2
]}

Manohar, Murli ^{[2
]}

Prakash, Om ^{[1
]}

Chanda, D. ^{[1
]}

Khan, Feroz ^{[1
]}

Chanotiya, C. S. ^{[1
]}

Shanker, Karuna ^{[1
]}

Dwivedi, Anila ^{[2
]}

Konwar, Rituraj ^{[2
]}

Negi, Arvind S. ^{[1
]}

机构：

[1] CSIR, CIMAP, Lucknow 226015, UP, India

[2] CSIR, CDRI, Lucknow 22612, UP, India

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2013年 / 137卷

关键词：

Combretastatin A4; Breast cancer; Tubulin polymerization inhibition; Estrogenicity; Antiestrogenicity; Acute oral toxicity; RESVERATROL OLIGOMERS; LACTATE-DEHYDROGENASE; STILBENES; AGENTS; DERIVATIVES; INHIBITION; APOPTOSIS; BARK; CELL; PROLIFERATION;

D O I：

10.1016/j.jsbmb.2013.02.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Combretastatin A4 analogues were synthesized on steroidal framework from gallic acid with a possibility of anti-breast cancer agents. Twenty two analogues were synthesized and evaluated for cytotoxicity against human breast cancer cell lines (MCF-7 & MDA-MB 231). The best analogue 22 showed potent antitubulin effect. Docking experiments also supported strong binding affinity of 22 to microtubule polymerase. In cell cycle analysis, 22 induced apoptosis in MCF-7 cells significantly. It was found to be non-toxic up to 300 mg/kg dose in Swiss albino mice in acute oral toxicity. This article is part of a Special Issue entitled "Synthesis and biological testing of steroid derivatives as inhibitors". (C) 2013 Elsevier Ltd. All rights reserved.

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页码：332 / 344

页数：13

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