Ru(II)-catalyzed asymmetric cyclopropanation using chiral diphenylphosphino(oxazolinyl)quinoline ligands

被引：27
|
作者：
Park, SW
Son, JH
Kim, SG
Ahn, KH
机构：
[1] Pohang Univ Sci & Technol, Dept Chem, Pohang 790784, South Korea
[2] Pohang Univ Sci & Technol, Ctr Biofunct Mol, Pohang 790784, South Korea
来源：
TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 10期
关键词：
D O I：
10.1016/S0957-4166(99)00190-1
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Several chiral 8-diphenylphosphino-2-oxazolinylquinolines were synthesized starting from 2-cyano-8-hydroxyquinoline. These N,N,P-chelates were successfully employed in the Ru(II)-catalyzed asymmetric cyclopropanation reactions of diazo-alkenes. The catalytic system exhibited good reactivity and high thermal stability and provided high yields in the intramolecular cyclopropanation, albeit somewhat decreased enantioselectivities compared to known catalytic systems. A dramatic dependency of the enantioselectivity on the substituents of the oxazoline ring was observed. (C) 1999 Elsevier Science Ltd. All rights reserved.
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页码：1903 / 1911
页数：9
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