MiR-206 inhibits gastric cancer proliferation in part by repressing CyclinD2

被引：125

作者：

Zhang, Lin ^{[1
]}

Liu, Xiaodong ^{[1
]}

Jin, Haifeng ^{[1
]}

Guo, Xuegang ^{[1
]}

Xia, Limin ^{[1
]}

Chen, Zhangqian ^{[1
]}

Bai, Ming ^{[1
]}

Liu, Jian ^{[1
]}

Shang, Xin ^{[1
]}

Wu, Kaichun ^{[1
]}

Pan, Yanglin ^{[1
]}

Fan, Daiming ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Xijing Hosp Digest Dis, State Key Lab Canc Biol, Xian 710032, Shaanxi Provinc, Peoples R China

来源：

CANCER LETTERS | 2013年 / 332卷 / 01期

基金：

中国国家自然科学基金;

关键词：

MiR-206; Proliferation; CyclinD2; Gastric cancer; BREAST-CANCER; CELL-LINES; POSTTRANSCRIPTIONAL REGULATION; MESSENGER-RNA; C-ELEGANS; EXPRESSION; MICRORNAS; GENE; OVEREXPRESSION; METASTASIS;

D O I：

10.1016/j.canlet.2013.01.023

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this study, we detected miR-206 expression in gastric cancer (GC) and further investigated its effects on GC cell growth in vitro and in vivo. MiR-206 expression was found to be significantly decreased in 30 GC samples and GC cell lines by Real time-KR. Restoration of miR-206 reduced cell growth and colony forming ability in GC cells with G0/G1 cell cycle arrest. Further studies demonstrated that miR-206 could suppress GC cells proliferation at least partially through targeting the CyclinD2 (CCND2). Therefore, we provided evidence that miR-206 was a potential tumor suppressor and may be used as a therapeutic target for gastric cancer. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：94 / 101

页数：8

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