Global epidemiology of community-associated methicillin resistant Staphylococcus aureus (CA-MRSA)

被引：316

作者：

Mediavilla, Jose R. ^{[1
]}

Chen, Liang ^{[1
]}

Mathema, Barun ^{[1
]}

Kreiswirth, Barry N. ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, Int Ctr Publ Hlth, Publ Hlth Res Inst, TB Ctr, Newark, NJ 07103 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2012年 / 15卷 / 05期

关键词：

USA300; EMERGENCE; VIRULENCE; CLONE; EVOLUTION; LINEAGE; STRAIN; COLONIZATION; ORIGIN; SKIN;

D O I：

10.1016/j.mib.2012.08.003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

During the 1990s, various reports of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections appeared in the literature, caused by novel strains genetically distinct from traditional healthcare-associated MRSA (HA-MRSA). Numerous lineages of CA-M RSA have since emerged on every continent, several of which have spread internationally, most notably USA300. CA-MRSA strains are increasingly implicated in nosocomial infections, and may eventually displace HA-MRSA strains in hospitals. Consequently, distinctions based on clinical epidemiology and susceptibility are becoming less relevant, arguing in favor of genotypic definitions. We review the current molecular epidemiology of CA-MRSA with respect to genetic diversity, global distribution, and factors related to its emergence and spread.

引用

页码：588 / 595

页数：8

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