The Role of Interleukin-33 in Rhinitis

被引：31
|
作者：
Rogala, Barbara [1 ]
Glueck, Joanna [2 ]
机构：
[1] Med Univ Silesia, Chair & Clin Dept Internal Dis Allergol & Clin Im, PL-40952 Katowice, Poland
[2] Med Univ Silesia, Katowice, Poland
来源：
CURRENT ALLERGY AND ASTHMA REPORTS | 2013年 / 13卷 / 02期
关键词：
Interleukin-33; IL-33/ST2; Th2-mediated response; Rhinitis; Pathogenesis; Allergic inflammation; T cells; Basophils; Eosinophils; Mast cells; CYTOKINE IL-33; MURINE MODEL; ANTI-IL-33; ANTIBODY; AIRWAY INFLAMMATION; ALLERGIC RHINITIS; ST2; GENE; T-CELLS; RECEPTOR; EXPRESSION; TYPE-2;
D O I：
10.1007/s11882-013-0338-z
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
IL-33, a member of the IL-1 cytokine family and a ligand to receptor ST2, has great potential to induce a T helper 2-type inflammatory response. IL-33 is proven to be released by epithelial cells during their injury by different environmental stimuli such as airborne allergens, viruses, and air pollutants. IL-33 acting as an endogenous danger signal is termed an alarmin. As such, this cytokine is considered to play a crucial role in an allergic inflammatory disease such as rhinitis. Recent investigations regarding the IL-33/ST2 axis involvement in Th2 inflammatory response and pathogenesis of rhinitis have been reviewed. The role of IL-33 as a novel promising therapeutic target has also been discussed.
引用
收藏
页码：196 / 202
页数：7
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