Bioactive constituents from the rhizomes of Dioscorea septemloba Thunb

被引：22

作者：

Zhang, Yi ^{[1
,2
]}

Chao, Liping ^{[1
]}

Ruan, Jingya ^{[1
]}

Zheng, Chang ^{[1
]}

Yu, Haiyang ^{[1
,2
]}

Qu, Lu ^{[2
]}

Han, Lifeng ^{[1
,2
]}

Wang, Tao ^{[1
,2
]}

机构：

[1] Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, 312 Anshanxi Rd, Tianjin 300193, Peoples R China

[2] Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin Key Lab TCM Chem & Anal, 312 Anshanxi Rd, Tianjin 300193, Peoples R China

来源：

FITOTERAPIA | 2016年 / 115卷

基金：

中国国家自然科学基金;

关键词：

Dioscorea septemloba Thunb; RAW; 264.7; cells; Anti-inflammatory activity; LIGNANS; FRUITS;

D O I：

10.1016/j.fitote.2016.10.011

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Eight new compounds, dioscorosides G (1), H-1 (2), H-2 (3), dioscorol B (4), dioscorosides I (5), J (6), K-1 (7), and K-2 (8), together with twelve known ones (9-20) were obtained from the rhizomes of Dioscorea septemloba. Their structures were elucidated by chemical and spectroscopic methods. Among the known isolates, 12-14, 18, and 20 were isolated from the Dioscoreae genus for the first time. While, 9-11, 15, and 16 were firstly obtained from the plant. Moreover, all the isolates were evaluated for in vitro anti-inflammatory potential using LPS-stimulated RAW 264.7 murine macrophages, and compounds 7, 11, 15, and 16 were found to display significant inhibition of nitrite production. (C) 2016 Elsevier B.V. All rights reserved.

引用

收藏

页码：165 / 172

页数：8

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