The Potential Role of Human Milk Oligosaccharides in Irritable Bowel Syndrome

被引：7

作者：

Sanz Morales, Patricia ^{[1
]}

Wijeyesekera, Anisha ^{[1
]}

Robertson, Margaret Denise ^{[2
]}

Jackson, Peter P. J. ^{[1
]}

Gibson, Glenn R. ^{[1
]}

机构：

[1] Univ Reading, Dept Food & Nutr Sci, Whiteknights, Reading RG66AH, England

[2] Univ Surrey, Fac Hlth & Med Sci, Dept Nutr Sci, Guildford GU27XH, Surrey, England

来源：

MICROORGANISMS | 2022年 / 10卷 / 12期

基金：

英国生物技术与生命科学研究理事会;

关键词：

human milk oligosaccharide; irritable bowel syndrome; gut microbiota; 2'fucosyllactose; Bifidobacterium; LOW FODMAP DIET; GUT MICROBIOTA; PEPPERMINT OIL; BOVINE-MILK; FECAL MICROBIOTA; GASTROINTESTINAL MICROBIOTA; PSYCHOLOGICAL THERAPIES; FRUCTO-OLIGOSACCHARIDES; CLINICAL-TRIAL; ROME III;

D O I：

10.3390/microorganisms10122338

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Irritable Bowel Syndrome (IBS) is the most common gastrointestinal (GI) disorder in Western populations and therefore a major public health/economic concern. However, despite extensive research, psychological and physiological factors that contribute to the aetiology of IBS remain poorly understood. Consequently, clinical management of IBS is reduced to symptom management through various suboptimal options. Recent evidence has suggested human milk oligosaccharides (HMOs) as a potential therapeutic option for IBS. Here, we review literature concerning the role of HMOs in IBS, including data from intervention and in vitro trials. HMO supplementation shows promising results in altering the gut microbiota and improving IBS symptoms, for instance by stimulating bifidobacteria. Further research in adults is required into HMO mechanisms, to confirm the preliminary results available to date and recommendations of HMO use in IBS.

引用

页数：17

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