Limbic encephalitis and type 1 diabetes with glutamic acid decarboxylase 65 (GAD65) autoimmunity: Improvement with high-dose intravenous immunoglobulin therapy

被引：13

作者：

Lopez-Sublet, M. ^{[1
]}

Bihan, H. ^{[2
]}

Reach, G. ^{[2
]}

Dupont, S. ^{[3
]}

Didelot, A. ^{[4
]}

Mourad, J. -J. ^{[1
]}

Krivitzky, A. ^{[1
]}

Dhote, R. ^{[1
]}

机构：

[1] Hop Avicenne, Postemergency Unit, Dept Internal Med, F-93009 Bobigny, France

[2] Univ Paris 13, Dept Endocrinol Diabet & Metab Dis, Ctr Rech Nutr Humaine, Avicenne Hosp,AP HP, Bobigny, France

[3] La Pitie Salpetriere Assistance Publ Hop Paris, Dept Neurol, Pitie Salpetriere, France

[4] Neurol Hosp, Dept Neurol, Lyon, France

来源：

DIABETES & METABOLISM | 2012年 / 38卷 / 03期

关键词：

Type; 1; diabetes; Glutamic acid decarboxylase 65 (GAD); Limbic encephalitis; Immunotherapy; Epilepsia; AUTOANTIBODIES; EPILEPSY; ANTIBODIES;

D O I：

10.1016/j.diabet.2012.02.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Glutamic acid decarboxylase antibodies (GAD-abs) are an immunological factor involved in type 1 diabetes and other diseases involving the central nervous system. This report is of a patient with type I diabetes and a rare case of non-paraneoplastic limbic encephalitis mediated by anti-GAD65 antibodies that improved with the use of immunosuppressive drugs. (C) 2012 Elsevier Masson SAS. All rights reserved.

引用

页码：273 / 275

页数：3

共 14 条

[1] Acute limbic encephalitis and glutamic acid decarboxylase antibodies: A reality? [J].

Blanc, F. ;

Ruppert, E. ;

Kleitz, C. ;

Valenti, M. P. ;

Cretin, B. ;

Humbel, R. L. ;

Honnorat, J. ;

Namer, I. J. ;

Hirsch, E. ;

Manning, L. ;

de Seze, J. .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2009, 287 (1-2) :69-71

[2] Mechanism of action of intravenous immunoglobulin and therapeutic considerations in the treatment of autoimmune neurologic diseases [J].

Dalakas, MC .

NEUROLOGY, 1998, 51 (06) :S2-S8

[3] High-dose intravenous immune globulin for stiff-person syndrome [J].

Dalakas, MC ;

Fujii, M ;

Li, M ;

Lutfi, B ;

Kyhos, J ;

McElroy, B .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (26) :1870-1876

[4] Stiff person syndrome -: Quantification, specificity, and intrathecal synthesis of GAD65 antibodies [J].

Dalakas, MC ;

Mian, L ;

Fujii, M ;

Jacobowitz, DM .

NEUROLOGY, 2001, 57 (05) :780-784

[5] Temporal-lobe epilepsy associated with glutamic-acid-decarboxylase autoantibodies [J].

Giometto, B ;

Nicolao, P ;

Macucci, M ;

Tavolato, B ;

Foxon, R ;

Bottazzo, GF .

LANCET, 1998, 352 (9126) :457-457

[6] Autoimmune limbic encephalitis: an expanding concept [J].

Honnorat, Jerome .

LANCET NEUROLOGY, 2010, 9 (01) :24-25

[7] Hu-antibody-positive patients with or without cancer have similar clinical profiles [J].

Llado, A. ;

Carpentier, A. F. ;

Honnorat, J. ;

Sillevis-Smitt, P. ;

Twijnstra, A. ;

Blanco, Y. ;

Hart, I. K. ;

Saiz, A. ;

Graus, F. .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2006, 77 (08) :996-997

[8] Effects of anti-glutamic acid decarboxylase antibodies associated with neurological diseases [J].

Manto, Mario-Ubaldo ;

Laute, Marie-Aline ;

Aguera, Michele ;

Rogemond, Veronique ;

Pandolfio, Massimo ;

Honnorat, Jerome .

ANNALS OF NEUROLOGY, 2007, 61 (06) :544-551

[9] Non-paraneoplastic limbic encephalitis associated with anti-glutamic acid decarboxylase antibodies [J].

Mata, Sabrina ;

Muscas, Gian Carlo ;

Naldi, Ilaria ;

Rosati, Eleonora ;

Paladini, Sergio ;

Cruciatti, Barbara ;

Bisulli, Francesca ;

Paganini, Marco ;

Mazzi, Gustavo ;

Sorbi, Sandro ;

Tinuper, Paolo .

JOURNAL OF NEUROIMMUNOLOGY, 2008, 199 (1-2) :155-159

[10] Autoantibodies to glutamic acid decarboxylase in patients with therapy-resistant epilepsy [J].

Peltola, J ;

Kulmala, P ;

Isojärvi, J ;

Saiz, A ;

Latvala, K ;

Palmio, J ;

Savola, K ;

Knip, M ;

Keränen, T ;

Graus, F .

NEUROLOGY, 2000, 55 (01) :46-50

← 1 2 →