The Cell Biology of TRIM5α

被引：12
|
作者：
Lukic, Zana [1 ]
Campbell, Edward M. [1 ]
机构：
[1] Loyola Univ Chicago, Stritch Sch Med, Dept Microbiol & Immunol, Maywood, IL 60153 USA
来源：
CURRENT HIV/AIDS REPORTS | 2012年 / 9卷 / 01期
关键词：
rhTRIM5alpha; Cytoplasmic bodies; HIV-1; Restriction factor; Signaling; 2;
D O I：
10.1007/s11904-011-0102-8
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The tripartite motif (TRIM)-containing proteins are involved in many cellular functions such as cell signaling, apoptosis, cell differentiation, and immune modulation. TRIM5 proteins, including TRIM5 alpha and TRIM-Cyp, are known to possess antiretroviral activity against many different retroviruses. Besides being retroviral restriction factors, TRIM5 proteins participate in other cellular functions that have recently emerged in the study of TRIM5 alpha. In this review, we discuss properties of TRIM5 alpha such as cytoplasmic body formation, protein turnover, and trafficking. Also, we discuss recent insights into innate immune modulation mediated by TRIM5 alpha, highlighting the various functions TRIM5 alpha has in cellular processes.
引用
收藏
页码：73 / 80
页数：8
相关论文
共 50 条
  • [41] Generation of human TRIM5α mutants with high HIV-1 restriction activity
    Pham, Q. T.
    Bouchard, A.
    Gruetter, M. G.
    Berthoux, L.
    GENE THERAPY, 2010, 17 (07) : 859 - 871
  • [42] Generation of human TRIM5α mutants with high HIV-1 restriction activity
    Q T Pham
    A Bouchard
    M G Grütter
    L Berthoux
    Gene Therapy, 2010, 17 : 859 - 871
  • [43] TRIM5α抗HIV-1功能的研究
    李岚
    陆庆宇
    张森燕
    王新泉
    吴昊
    首都医科大学学报, 2011, 32 (03) : 341 - 345
  • [44] Potent Lentiviral Restriction by a Synthetic Feline TRIM5 Cyclophilin A Fusion
    Dietrich, Isabelle
    Macintyre, Angela
    McMonagle, Elizabeth
    Price, Amanda J.
    James, Leo C.
    McEwan, William A.
    Hosie, Margaret J.
    Willett, Brian J.
    JOURNAL OF VIROLOGY, 2010, 84 (17) : 8980 - 8985
  • [45] TRIM5α associates with proteasomal subunits in cells while in complex with HIV-1 virions
    Lukic, Zana
    Hausmann, Stephane
    Sebastian, Sarah
    Rucci, Justin
    Sastri, Jaya
    Robia, Seth L.
    Luban, Jeremy
    Campbell, Edward M.
    RETROVIROLOGY, 2011, 8 : 93
  • [46] TRIM5α associates with proteasomal subunits in cells while in complex with HIV-1 virions
    Zana Lukic
    Stéphane Hausmann
    Sarah Sebastian
    Justin Rucci
    Jaya Sastri
    Seth L Robia
    Jeremy Luban
    Edward M Campbell
    Retrovirology, 8
  • [47] The Titer of the Lentiviral Vector Encoding Chimeric TRIM5α-HRH Gene is Reduced Due to Expression of TRIM5α-HRH in Producer Cells and the Negative Effect of Ef1α Promoter
    Urusov, F. A.
    Glazkova, D., V
    Tsyganova, G. M.
    Pozdyshev, D., V
    Bogoslovskaya, E., V
    Shipulin, G. A.
    MOLECULAR BIOLOGY, 2022, 56 (01) : 107 - 114
  • [48] Retrovirus Restriction Factor TRIM5α: The Mechanism of Action and Prospects for Use in Gene Therapy of HIV Infection
    Glazkova, D. V.
    Urusov, F. A.
    Bogoslovskaya, E. V.
    Shipulin, G. A.
    MOLECULAR BIOLOGY, 2020, 54 (05) : 623 - 632
  • [49] Unique Spectrum of Activity of Prosimian TRIM5α against Exogenous and Endogenous Retroviruses
    Rahm, Nadia
    Yap, Melvyn
    Snoeck, Joke
    Zoete, Vincent
    Munoz, Miguel
    Radespiel, Ute
    Zimmermann, Elke
    Michielin, Olivier
    Stoye, Jonathan P.
    Ciuffi, Angela
    Telenti, Amalio
    JOURNAL OF VIROLOGY, 2011, 85 (09) : 4173 - 4183
  • [50] Determinants for the Rhesus Monkey TRIM5α-mediated Block of the Late Phase of HIV-1 Replication
    Sakuma, Ryuta
    Ohmine, Seiga
    Ikeda, Yasuhiro
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (06) : 3784 - 3793
12345