The Cell Biology of TRIM5α

被引：12
|
作者：
Lukic, Zana [1 ]
Campbell, Edward M. [1 ]
机构：
[1] Loyola Univ Chicago, Stritch Sch Med, Dept Microbiol & Immunol, Maywood, IL 60153 USA
来源：
CURRENT HIV/AIDS REPORTS | 2012年 / 9卷 / 01期
关键词：
rhTRIM5alpha; Cytoplasmic bodies; HIV-1; Restriction factor; Signaling; 2;
D O I：
10.1007/s11904-011-0102-8
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The tripartite motif (TRIM)-containing proteins are involved in many cellular functions such as cell signaling, apoptosis, cell differentiation, and immune modulation. TRIM5 proteins, including TRIM5 alpha and TRIM-Cyp, are known to possess antiretroviral activity against many different retroviruses. Besides being retroviral restriction factors, TRIM5 proteins participate in other cellular functions that have recently emerged in the study of TRIM5 alpha. In this review, we discuss properties of TRIM5 alpha such as cytoplasmic body formation, protein turnover, and trafficking. Also, we discuss recent insights into innate immune modulation mediated by TRIM5 alpha, highlighting the various functions TRIM5 alpha has in cellular processes.
引用
收藏
页码：73 / 80
页数：8
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