Synthesis and biological evaluation of novel C (7) modified chrysin analogues as antibacterial agents

被引：120

作者：

Babu, KS

Babu, TH

Srinivas, PV

Kishore, KH

Murthy, USN

Rao, JM ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem 1, Hyderabad 500007, Andhra Pradesh, India

[2] Indian Inst Chem Technol, Div Biol, Hyderabad 500007, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 01期

关键词：

chrysin; Oroxylum indicum; spacers; antibacterial activity; amines;

D O I：

10.1016/j.bmcl.2005.09.009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The natural product, chrysin (5,7-dihydroxy flavone), obtained from Oroxylum indicum, exhibits numerous biological activities including anticancer, anti-inflammatory, and antiallergic activities. Three series of chrysin analogues were prepared, in which chrysin and heterocyclic moieties are separated by 3-carbon, 4-carbon, and 6-carbon spacers. All the derivatives were screened for antibacterial activity against a panel of susceptible and resistant Gram-positive and Gram-negative organisms. It was observed that most of the derivatives displayed significant activity as compared to their parent compound (chrysin). (c) 2005 Elsevier Ltd. All rights reserved.

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页码：221 / 224

页数：4

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