Relation between the structure of some heterocyclic derivatives and other compounds, and their effects as enhancers or inhibitors of the luminol-H2O2-horseradish peroxidase chemiluminescence

The enhancement or inhibition produced by 4-hydroxyazobenzene, 4'-hydroxyazobenzene-2-carboxylic acid (HABA), 7-hydroxycoumarin, 7-hydroxy-4-methylcoumarin, 7-hydroxycoumarin-4-acetic acid, 4-hydroxypyridine, 6-hydroxyquinoline, vanillin, p-rosolic acid, phenylacetate, 4-phenylphenolacetate, 5-aminoquinoline and 5-aminoisoquinoline on the luminol-H2O2-horseradish peroxidase chemiluminescence were studied. These phenomena were compared with the effects produced by some enhancers known with similar structures to the previous compounds, such as, phenol, 4-phenylphenol, 4-hydroxycinnamic acid, 2-naphthol, 4-hydroxybenzaldehyde, phenolphthalein and 1-aminonaphthalene, The enhancer activity was related to particular structures of each compound, reaction rate constants with horseradish peroxidase, pH and enhancer concentration. (C) 1997 Elsevier Science S.A.