Haemocompatibility of DLC and TiC-TiN interlayers on titanium

被引:135
作者
Jones, MI [1 ]
McColl, IR
Grant, DM
Parker, KG
Parker, TL
机构
[1] Univ Nottingham, Sch Mech Mat Mfg Engn & Management, Nottingham NG7 2RD, England
[2] Univ Nottingham, QMC, Sch Biomed Sci, Nottingham NG7 2UH, England
关键词
diamond-like carbon; haemocompatibility; interlayers; plasma-assisted chemical vapour deposition;
D O I
10.1016/S0925-9635(98)00426-9
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
An interlayer approach was adopted to achieve adequate adhesion between a DLC coating deposited by plasma-assisted CVD and a titanium substrate as part of a study to coat a bi-leaflet heart valve prosthesis. The interlayers (TiC and TiN) were deposited by d.c. ion plating. TiN was also deposited by reactive r.f. sputtering. The substrate, interlayers and DLC were assessed for haemocompatibility and thrombogenicity using a dynamic blood method and interactions with rabbit blood platelets, respectively. The adhesion, activation and morphology of the platelets were determined by stereological techniques using SEM. All surfaces were assessed topographically by stylus profilometry and AFM. Surface energies were compared by liquid drop goniometry. The structure and crystallographic orientation of the TiN interlayers were determined using XRD. The coatings produced no haemolytic effect, except in the case of TiN deposited by reactive r.f. sputtering which showed a significant effect after longer assessment periods. In contrast to the DLC coating, all of the interlayers showed a slight tendency towards thrombus formation during the later stages of incubation. Platelet spreading correlated with the surface energy of the coatings. (C) 1999 Elsevier Science S.A. All rights reserved.
引用
收藏
页码:457 / 462
页数:6
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