Development of Subretinal Fibrosis After Anti-VEGF Treatment in Neovascular Age-Related Macular Degeneration

被引：75

作者：

Hwang, John C. ^{[1
]}

Del Priore, Lucian V. ^{[1
,2
]}

Freund, K. Bailey ^{[2
]}

Chang, Stanley ^{[1
]}

Iranmanesh, Reza ^{[1
]}

机构：

[1] Columbia Univ, Med Ctr, Edward S Harkness Eye Inst, New York, NY 10032 USA

[2] Retina Macula Consultants New York, New York, NY USA

来源：

OPHTHALMIC SURGERY LASERS & IMAGING | 2011年 / 42卷 / 01期

关键词：

TISSUE GROWTH-FACTOR; CHOROIDAL NEOVASCULARIZATION;

D O I：

10.3928/15428877-20100924-01

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

BACKGROUND AND OBJECTIVE: To describe the development or progression of subfoveal fibrosis after anti-vascular endothelial growth factor (VEGF) therapy in the absence of significant subfoveal hemorrhage in neovascular age-related macular degeneration. PATIENTS AND METHODS: Retrospective case series. RESULTS: Seven eyes of seven patients with neovascular age-related macular degeneration developed subfoveal fibrosis after anti-VEGF therapy in the absence of significant subfoveal hemorrhage. Five of seven patients experienced vision loss of 0.3 logarithm of the minimum angle of resolution units or greater. CONCLUSION: Subfoveal fibrosis may develop or progress in neovascular age-related macular degeneration despite the absence of significant subfoveal hemorrhage and treatment with anti-VEGF. Development of anti-fibrotic therapeutics may be beneficial in reducing the incidence of subretinal fibrosis.

引用

页码：6 / 11

页数：6

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