Fish oil and neurovascular control in humans

被引:16
作者
Carter, Jason R. [1 ]
Schwartz, Christopher E. [1 ]
Yang, Huan [1 ]
Joyner, Michael J. [2 ]
机构
[1] Michigan Technol Univ, Dept Kinesiol & Integrat Physiol, Houghton, MI 49931 USA
[2] Mayo Clin, Dept Anesthesiol, Rochester, MN USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 2012年 / 303卷 / 04期
关键词
muscle sympathetic nerve activity; autonomic activity; omega-3 fatty acids; HEART-RATE-VARIABILITY; POLYUNSATURATED FATTY-ACIDS; SYMPATHETIC-NERVE ACTIVITY; BLOOD-PRESSURE; DIETARY OMEGA-3-FATTY-ACIDS; CARDIAC NORADRENALINE; EICOSAPENTAENOIC ACID; SUPPLEMENTATION; METAANALYSIS; FREQUENCY;
D O I
10.1152/ajpheart.00353.2012
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Carter JR, Schwartz CE, Yang H, Joyner MJ. Fish oil and neurovascular control in humans. Am J Physiol Heart Circ Physiol 303: H450-H456, 2012. First published June 15, 2012; doi: 10.1152/ajpheart.00353.2012.-The antihypertensive influence of fish oil is controversial, and the mechanisms remain unclear. Because the inverse relation between fish oil and hypertension appears to be partially dependent on the degree of hypertension, we tested the hypothesis that fish oil would elicit more dramatic reductions in mean arterial pressure (MAP) and muscle sympathetic nerve activity (MSNA) in prehypertensive (PHT) compared with normotensive (NT) subjects. Resting MAP, MSNA, and heart rate (HR) were examined before and after 8 wk of fish oil (9 g/day; 1.6 g eicosapentaenoic acid and 1.1 g docosahexaenoic acid) or placebo (olive oil; 9 g/day) in 38 NT (19 fish oil; 19 placebo) and 29 PHT (15 fish oil; 14 placebo) volunteers. Fish oil did not alter resting MAP, MSNA, or HR in either NT (80 +/- 1 to 80 +/- 1 mmHg; 11 +/- 2 to 10 +/- 1 bursts/min; 71 +/- 2 to 71 +/- 2 beats/min) or PHT (88 +/- 2 to 87 +/- 1 mmHg; 11 +/- 2 to 10 +/- 2 bursts/min; 73 +/- 2 to 73 +/- 2 beats/min) subjects. When NT and PHT groups were consolidated, analysis of covariance confirmed that pretreatment resting MAP was not associated with changes in MSNA after fish oil. In contrast, pretreatment resting HR was correlated with changes in MSNA (r = 0.47; P = 0.007) and MAP (r = 0.42; P < 0.007) after fish oil but not placebo. In conclusion, fish oil did not alter sympathetic neural control in NT or PHT subjects. However, our findings suggest that fish oil is associated with modest sympathoinhibition in individuals with higher resting heart rates, a finding that is consistent with a recent meta-analysis examining the relations among fish oil, HR, and the risk of cardiovascular disease.
引用
收藏
页码:H450 / H456
页数:7
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