Synthesis of benzofulvenes through chemoselective Sonogashira and Barluenga couplings of ortho ethynyl-N-tosylhydrazones and cycloisomerization

被引：10

作者：

Aziz, Jessy ^{[1
]}

Brion, Jean-Daniel ^{[1
]}

Alami, Mouad ^{[1
]}

Hamze, Abdallah ^{[1
]}

机构：

[1] Univ Paris 11, CNRS, BioCIS UMR 8076,Fac Pharm, Lab Chim Therapeut,Equipe Labellisee Ligue Canc,L, F-92296 Chatenay Malabry, France

来源：

RSC ADVANCES | 2015年 / 5卷 / 91期

关键词：

BOND FORMATION; 3-SUBSTITUTED INDAZOLES; METAL CARBENE; ARYL HALIDES; DERIVATIVES; HYDRAZONES; AMINES; ROUTE;

D O I：

10.1039/c5ra14459k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chemoselective synthesis of ortho ethynylhydrazones 7 derived from 2-iodoacetophenone via a Sonogashira coupling is reported for the first time. In this challenging transformation, a site-selective coupling in the presence of a hydrazone function was developed. These compounds represent useful intermediates for the synthesis of benzofulvenes through a sequence of palladium-catalyzed cross-coupling and palladium-catalyzed 5-exo-dig cyclization.

引用

收藏

页码：74391 / 74398

页数：8

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