Synthesis and biological evaluation of novel formyl-pyrazoles bearing coumarin moiety as potent antimicrobial and antioxidant agents

被引：88

作者：

Renuka, Nagamallu ^{[1
]}

Kumar, Kariyappa Ajay ^{[1
]}

机构：

[1] Univ Mysore, Yuvarajas Coll, Dept Chem, Mysore 570005, Karnataka, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 23期

关键词：

Antibacterial; Antifungal; Antioxidant; Heterocycles; MIC; ALTERNARIOL;

D O I：

10.1016/j.bmcl.2013.09.053

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of coumarin appended formyl-pyrazoles 14-18 were synthesized by a simple and accessible approach. The reaction of 8-acetyl-4-methyl-7-hydroxy coumarin 3 and phenyl hydrazine hydrochlorides 4-8 produces the intermediate compounds 8-acetyl-4-methyl-7-hydroxy coumarin hydrazones 9-13. The reaction of compounds 9-13 and DMF in the presence of POCl3 yielded formyl-pyrazoles bearing coumarin moiety 14-18 in good yield. The synthesized new compounds 14-18 and the intermediates 8-acetyl-4-methyl-7-hydroxy coumarin hydrazones 9-13 prepared were screened in vitro for their antibacterial, antifungal antioxidant activities. The compounds 12 and 17 having chloro substitution exhibited promising antifungal and antibacterial activity against the different organisms tested. The compound 17 showed remarkable DPPH radical scavenging ability. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：6406 / 6409

页数：4

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