Attenuated HSP70 response in skeletal muscle of aged rats following contractile activity

被引：67

作者：

Vasilaki, A ^{[1
]}

Jackson, MJ ^{[1
]}

McArdle, A ^{[1
]}

机构：

[1] Univ Liverpool, Dept Med, Liverpool L69 3GA, Merseyside, England

来源：

MUSCLE & NERVE | 2002年 / 25卷 / 06期

关键词：

aging; exercise; HSF; HSP; stress proteins;

D O I：

10.1002/mus.10094

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The aim of this study was to investigate the production of HSP70 in gastrocnemius muscles from adult (6-month-old) and aged (28-month-old) rats following contractile activity. At 24 h following a period of repeated isometric contractions, muscles from adult rats contained significantly elevated levels of HSP70 compared with nonexercised muscle. This was not evident in muscles from aged rats. This attenuated response may play a major role in development of the age-related functional deficit that occurs in skeletal muscle. (C) 2002 Wiley Periodicals, Inc.

引用

页码：902 / 905

页数：4

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