Silver-Catalyzed Isocyanide-Alkyne Cycloaddition: A General and Practical Method to Oligosubstituted Pyrroles

被引：276

作者：

Liu, Jianquan ^{[1
]}

Fang, Zhongxue ^{[1
]}

Zhang, Qian ^{[1
]}

Liu, Qun ^{[1
]}

Bi, Xihe ^{[1
,2
]}

机构：

[1] NE Normal Univ, Dept Chem, Changchun 130024, Peoples R China

[2] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 27期

关键词：

alkynes; cycloaddition; isocyanides; oligosubstituted pyrroles; silver carbonate; C-H; ANTIINFLAMMATORY 4,5-DIARYLPYRROLES; EFFICIENT SYNTHESIS; TERMINAL ALKYNES; ACETYLENES; FURANS; DERIVATIVES; COMPLEXES; IMINES; ISOCYANOACETATE;

D O I：

10.1002/anie.201302024

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ag2CO3 is the key: The transition-metal-catalyzed cycloaddition of isocyanides and unactivated terminal alkynes has been realized with Ag2CO3 as a unique and robust catalyst (see scheme). The protocol is highly efficient, allowing a broad range of terminal and internal alkynes to react under base- and ligand-free conditions, generating synthetically useful oligosubstituted pyrroles in high yields. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6953 / 6957

页数：5

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