Evidence-Based Guidelines for Precision Risk Stratification-Based Screening (PRSBS) for Colorectal Cancer: Lessons Learned from the US Armed Forces: Consensus and Future Directions

被引：11

作者：

Avital, Itzhak ^{[1
,2
,3
,4
]}

Langan, Russell C. ^{[5
]}

Summers, Thomas A. ^{[3
,6
]}

Steele, Scott R. ^{[2
,3
,7
]}

Waldman, Scott A. ^{[8
,9
]}

Backman, Vadim ^{[10
]}

Yee, Judy ^{[11
]}

Nissan, Aviram ^{[3
,4
,12
]}

Young, Patrick ^{[13
]}

Womeldorph, Craig ^{[13
]}

Mancusco, Paul ^{[14
]}

Mueller, Renee ^{[14
]}

Noto, Khristian ^{[14
]}

Grundfest, Warren ^{[15
,16
,27
]}

Bilchik, Anton J. ^{[3
,4
,17
,18
,19
]}

Protic, Mladjan ^{[3
,4
,20
,21
]}

Daumer, Martin ^{[4
,22
]}

Eberhardt, John ^{[23
]}

Man, Yan Gao ^{[24
]}

Bruecher, Bjoern L. D. M. ^{[1
,2
,4
,25
]}

Stojadinovic, Alexander ^{[1
,2
,3
,4
,26
]}

机构：

[1] Bon Secours Canc Inst, Richmond, VA USA

[2] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA

[3] United States Mil Canc Inst, Bethesda, MD USA

[4] Theodor Billroth Acad, Int Consortium Res Excellence, INCORE, Munich, Germany

[5] Georgetown Univ Hosp, Washington, DC 20007 USA

[6] Walter Reed Natl Mil Med Ctr, Dept Pathol, Bethesda, MD 20889 USA

[7] Madigan Army Med Ctr, Dept Surg, Tacoma, WA 98431 USA

[8] Thomas Jefferson Univ, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

[9] Thomas Jefferson Univ, Jefferson Med Coll, Dept Pharmacol & Expt Therapeut, Philadelphia, PA 19107 USA

[10] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA

[11] Univ Calif San Francisco, San Francisco Sch Med Radiol & Biomed Imaging, San Francisco, CA 94143 USA

[12] Hadassah Hebrew Univ, Med Ctr, Dept Surg, Jerusalem, Israel

[13] Walter Reed Natl Mil Med Ctr, Dept Med, Div Gastroenterol, Bethesda, MD 20889 USA

[14] MD Anderson Canc Ctr Orlando, Orlando, FL USA

[15] Telemed & Adv Technol Res Ctr West, Los Angeles, CA USA

[16] US FDA, Los Angeles, CA USA

[17] John Wayne Canc Inst, Santa Monica, CA USA

[18] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA

[19] Calif Oncol Res Ctr, CA Diagnost, Los Angeles, CA USA

[20] Clin Ctr Vojvodina, Clin Abdominal Endocrine & Transplantat Surg, Novi Sad, Serbia

[21] Univ Novi Sad, Fac Med, Novi Sad 21000, Serbia

[22] Sylvia Lawry Ctr MS Res, Munich, Germany

[23] DecisionQ Corp, Washington, DC USA

[24] Henry Jackson Fdn Adv Mil Med, Diagnost & Translat Res Ctr, Gaithersburg, MD USA

[25] Theodor Billroth Acad, Munich, Germany

[26] Walter Reed Natl Mil Med Ctr, Dept Surg, Div Surg Oncol, Bethesda, MD 20889 USA

[27] Univ Calif Los Angeles, Los Angeles, CA USA

来源：

JOURNAL OF CANCER | 2013年 / 4卷 / 03期

关键词：

cancer screening; risk identification; colon; rectal; colorectal cancer; evidence-based medicine; consensus; HEAT-STABLE ENTEROTOXIN; GUANYLYL CYCLASE-C; CONTRAST BARIUM ENEMA; COLON-CANCER; STEM-CELLS; COMPUTED-TOMOGRAPHY; VIRTUAL COLONOSCOPY; PROSPECTIVE MULTICENTER; METHYLATION MARKERS; RACIAL DISPARITIES;

D O I：

10.7150/jca.5834

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer (CRC) is the third most common cause of cancer-related death in the United States (U. S.), with estimates of 143,460 new cases and 51,690 deaths for the year 2012. Numerous organizations have published guidelines for CRC screening; however, these numerical estimates of incidence and disease-specific mortality have remained stable from years prior. Technological, genetic profiling, molecular and surgical advances in our modern era should allow us to improve risk stratification of patients with CRC and identify those who may benefit from preventive measures, early aggressive treatment, alternative treatment strategies, and/or frequent surveillance for the early detection of disease recurrence. To better negotiate future economic constraints and enhance patient outcomes, ultimately, we propose to apply the principals of personalized and precise cancer care to risk-stratify patients for CRC screening (Precision Risk Stratification-Based Screening, PRSBS). We believe that genetic, molecular, ethnic and socioeconomic disparities impact oncological outcomes in general, those related to CRC, in particular. This document highlights evidence-based screening recommendations and risk stratification methods in response to our CRC working group private-public consensus meeting held in March 2012. Our aim was to address how we could improve CRC risk stratification-based screening, and to provide a vision for the future to achieving superior survival rates for patients diagnosed with CRC.

引用

页码：172 / 192

页数：21

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