Induction of Both Local Immune Response in Mice and Protection in a Rabbit Model by Intranasal Immunization with Modified Vaccinia Ankara Virus Expressing a Secreted Form of Bovine Herpesvirus 1 Glycoprotein D

被引：13

作者：

Del Medico Zajac, Maria Paula ^{[1
,2
]}

Adriana Zanetti, Flavia ^{[1
,2
]}

Soledad Esusy, Maria ^{[1
]}

Rodolfo Federico, Carlos ^{[1
,2
]}

Zabal, Osvaldo ^{[3
]}

Rafael Valera, Alejandro ^{[4
]}

Calamante, Gabriela ^{[1
]}

机构：

[1] Inst Nacl Tecnol Agr CICVyA INTA, Inst Biotecnol, Hurlingham, Argentina

[2] Consejo Nacl Invest Cient & Tecn, Buenos Aires, DF, Argentina

[3] Inst Nacl Tecnol Agr CICVyA INTA, Inst Virol, Hurlingham, Argentina

[4] Univ Nacl La Plata, Fac Ciencias Vet, Catedra Virol, La Plata, Buenos Aires, Argentina

来源：

VIRAL IMMUNOLOGY | 2017年 / 30卷 / 01期

关键词：

veterinary; vaccines; vectors; RESPIRATORY SYNCYTIAL VIRUS; MUCOSAL IMMUNIZATION; BOOST IMMUNIZATION; VECTORED VACCINES; INFLUENZA-VIRUS; MVA; REPLICATION; TYPE-1; CATTLE; DNA;

D O I：

10.1089/vim.2016.0090

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study, we evaluated the immunogenicity and efficacy of mucosal delivery of a recombinant modified vaccinia Ankara virus (MVA) expressing the secreted version of bovine herpesvirus type 1 (BoHV-1) glycoprotein D (MVA-gDs) without addition of adjuvant in two animal models. First, we demonstrated the capability of MVA-gDs of inducing both local and systemic anti-gD humoral immune response after intranasal immunization of mice. Then, we confirmed that two doses of MVA-gDs administered intranasally to rabbits induced systemic anti-gD antibodies and conferred protection against BoHV-1 challenge. Our results show the potential of using MVA as a vector for the rational design of veterinary vaccines capable of inducing specific and protective immune responses both at local and systemic level.

引用

页码：70 / 76

页数：7

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