Halting metastasis through CXCR4 inhibition

被引：54

作者：

Ramsey, Deborah M. ^{[1
]}

McAlpine, Shelli R. ^{[1
]}

机构：

[1] Univ New S Wales, Dept Chem, Sydney, NSW 2052, Australia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 01期

关键词：

CXCR4; SDF-1; Metastasis; Cancer; Heat shock protein 90; CHEMOKINE RECEPTORS; CANCER CELLS; SMALL-MOLECULE; POOR SURVIVAL; PHASE-II; EXPRESSION; MIGRATION; HSP90; SDF-1; RECOGNITION;

D O I：

10.1016/j.bmcl.2012.10.138

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Metastasis occurs when cancer cells leave the primary tumor site and migrate to distant parts of the body. The CXCR4-SDF-1 pathway facilitates this migration, and its expression has become the hallmark of several metastatic cancers. Targeted approaches are currently being developed to inhibit this pathway, and several candidates are now in clinical trials. Continued exploration of CXCR4 inhibitors will generate compounds that have improved activity over current candidates. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：20 / 25

页数：6

共 54 条

[1] Filopodia and adhesion in cancer cell motility [J].

Arjonen, Antti ;

Kaukonen, Riina ;

Ivaska, Johanna .

CELL ADHESION & MIGRATION, 2011, 5 (05) :421-430

[2] HMGA1 Induces Intestinal Polyposis in Transgenic Mice and Drives Tumor Progression and Stem Cell Properties in Colon Cancer Cells [J].

Belton, Amy ;

Gabrovsky, Alexander ;

Bae, Young Kyung ;

Reeves, Ray ;

Iacobuzio-Donahue, Christine ;

Huso, David L. ;

Resar, Linda M. S. .

PLOS ONE, 2012, 7 (01)

[3]

Brzoska E., 2012, BIOL C IN PRESS 0914

[4] CXCL-12/stromal cell-derived factor-1α transactivates HER2-neu in breast cancer cells by a novel pathway involving Src kinase activation [J].

Cabioglu, N ;

Summy, J ;

Miller, C ;

Parikh, NU ;

Sahin, AA ;

Tuzlali, S ;

Pumiglia, K ;

Gallick, GE ;

Price, JE .

CANCER RESEARCH, 2005, 65 (15) :6493-6497

[5] Chemokine receptors in advanced breast cancer: differential expression in metastatic disease sites with diagnostic and therapeutic implications [J].

Cabioglu, N. ;

Sahin, A. A. ;

Morandi, P. ;

Meric-Bernstam, F. ;

Islam, R. ;

Lin, H. Y. ;

Bucana, C. D. ;

Gonzalez-Angulo, A. M. ;

Hortobagyi, G. N. ;

Cristofanilli, M. .

ANNALS OF ONCOLOGY, 2009, 20 (06) :1013-1019

[6] Chemokine Signaling Directs Trunk Lymphatic Network Formation along the Preexisting Blood Vasculature [J].

Cha, Young Ryun ;

Fujita, Misato ;

Butler, Matthew ;

Isogai, Sumio ;

Kochhan, Eva ;

Siekmann, Arndt F. ;

Weinstein, Brant M. .

DEVELOPMENTAL CELL, 2012, 22 (04) :824-836

[7] CXCL12/CXCR4 transactivates HER2 in lipid rafts of prostate cancer cells and promotes growth of metastatic deposits in bone [J].

Chinni, Sreenivasa R. ;

Yamamoto, Hamilto ;

Dong, Zhong ;

Sabbota, Aaron ;

Bonfil, R. Daniel ;

Cher, Michael L. .

MOLECULAR CANCER RESEARCH, 2008, 6 (03) :446-457

[8] Semi-mechanistic Population Pharmacokinetic Model of Multivalent Trastuzumab Emtansine in Patients with Metastatic Breast Cancer [J].

Chudasama, V. L. ;

Stark, F. Schaedeli ;

Harrold, J. M. ;

Tibbitts, J. ;

Girish, S. R. ;

Gupta, M. ;

Frey, N. ;

Mager, D. E. .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2012, 92 (04) :520-527

[9] Single-Cell Analysis of Murine Long-Term Hematopoietic Stem Cells Reveals Distinct Patterns of Gene Expression during Fetal Migration [J].

Ciriza, Jesus ;

Hall, Dominique ;

Lu, Alison ;

De Sena, Joseph Robert ;

Al-Kuhlani, Mufadhal ;

Garcia-Ojeda, Marcos E. .

PLOS ONE, 2012, 7 (01)

[10] Dual Blockade of the Homeostatic Chemokine CXCL12 and the Proinflammatory Chemokine CCL2 Has Additive Protective Effects on Diabetic Kidney Disease [J].

Darisipudi, Murthy N. ;

Kulkarni, Onkar P. ;

Sayyed, Sufyan G. ;

Ryu, Mi ;

Migliorini, Adriana ;

Sagrinati, Costanza ;

Parente, Eliana ;

Vater, Axel ;

Eulberg, Dirk ;

Klussmann, Sven ;

Romagnani, Paola ;

Anders, Hans-Joachim .

AMERICAN JOURNAL OF PATHOLOGY, 2011, 179 (01) :116-124

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