Who Benefits From Maintenance Therapy in Acute Promyelocytic Leukemia?

被引：1

作者：

Marzbani, Edmond ^{[1
]}

Estey, Elihu ^{[1
]}

机构：

[1] Univ Washington, Seattle Canc Care Alliance, Dept Med, Seattle, WA 98195 USA

来源：

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK | 2012年 / 10卷 / 08期

关键词：

TRANS-RETINOIC ACID; EVENT-FREE; CHEMOTHERAPY; SURVIVAL; INTERGROUP;

D O I：

10.6004/jnccn.2012.0104

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acute promyelocytic leukemia (APL) is remarkable for its upfront mortality rate from disseminated intravascular coagulation and its high cure rate with therapy. Although induction and consolidation regimens continue to evolve, newer approaches combine an anthracycline with or without cytarabine and the highly effective differentiating drugs all-trans retinoic acid and arsenic trioxide. Early trials showed a benefit of maintenance therapy on overall survival, although this benefit has been less clear in subsequent trials. This review assesses the differences in these trials and outlines a rational approach to maintenance therapy in APL, generally advising against maintenance in patients who underwent adequate consolidation therapy, particularly if they presented with low-risk disease (WBC < 10,000) and experienced molecular complete remission after completion of consolidation. (JNCCN 2012;10:1023-1028)

引用

页码：1023 / 1028

页数：6

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