Eucommia ulmoides Leaf Extract Ameliorates Steatosis Induced by High-fat Diet in Rats by Increasing Lysosomal Function

被引：40

作者：

Lee, Geum-Hwa ^{[1
]}

Lee, Hwa-Young ^{[2
,3
]}

Park, Sun-Ah ^{[1
]}

Shin, Tai-Sun ^{[4
]}

Chae, Han-Jung ^{[1
,2
,3
]}

机构：

[1] Chonbuk Natl Univ Hosp, Nonclin Evaluat Ctr, Biomed Res Inst, Jeonju 54907, Chonbuk, South Korea

[2] Chonbuk Natl Univ, Med Sch, Dept Pharmacol, Jeonju 54896, Chonbuk, South Korea

[3] Chonbuk Natl Univ, Med Sch, New Drug Dev Inst, Jeonju 54896, Chonbuk, South Korea

[4] Chonnam Natl Univ, Coll Human Ecol, Div Food & Nutr, Gwang Ju 61186, South Korea

来源：

NUTRIENTS | 2019年 / 11卷 / 02期

关键词：

NAFLD; ER stress; Eucommia ulmoides leaf; autophagy; mTOR; OXIDATIVE STRESS; OLIV; PATHWAY; DAMAGE; DEATH;

D O I：

10.3390/nu11020426

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The recent discovery that the impairment of autophagic flux in non-alcoholic fatty liver disease (NAFLD) might be a strong determining factor in steatosis suggests the potential of therapeutic control of autophagic flux with natural agents in restoring NAFLD. We investigated the potential of Eucommia ulmoides leaf extract (EUL) to control dyslipidemia in NAFLD. EUL supplementation (200 mg/kg) promoted recovery from high fat diet (HFD)-induced lipid dysmetabolism. This hepatoprotective efficacy was accompanied by suppression of endoplasmic reticulum (ER) stress, enhancing lysosomal functions, and thereby increasing autophagic flux. We found a strong indication that inhibition of the mTOR-ER stress pathway was related to the enhanced autophagic flux. However, the direct antioxidative effect of EUL on cytoprotection cannot be ruled out as a significant contributing factor in NAFLD. Our findings will aid in further elucidating the mechanism of the anti-steatosis activity of EUL and highlight the therapeutic potential of EUL in the treatment of NAFLD.

引用

页数：15

共 29 条

[21] Hepatic leukocyte immunoglobulin-like receptor B4 (LILRB4) attenuates nonalcoholic fatty liver disease via SHP1-TRAF6 pathway [J].

Lu, Yao ;

Jiang, Zhou ;

Dai, Haijiang ;

Miao, Rujia ;

Shu, Jingxian ;

Gu, Haotian ;

Liu, Xing ;

Huang, Zhijun ;

Yang, Guoping ;

Chen, Alex F. ;

Yuan, Hong ;

Li, Ying ;

Cai, Jingjing .

HEPATOLOGY, 2018, 67 (04) :1303-1319

[22] Endoplasmic reticulum stress involved in high-fat diet and palmitic acid-induced vascular damages and fenofibrate intervention [J].

Lu, Yunxia ;

Cheng, Jingjing ;

Chen, Li ;

Li, Chaofei ;

Chen, Guanjun ;

Gui, Li ;

Shen, Bing ;

Zhang, Qiu .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 458 (01) :1-7

[23] Anti-Inflammatory Activity of Iridoid and Catechol Derivatives from Eucommia ulmoides Oliver [J].

Luo, Dan ;

Or, Terry C. T. ;

Yang, Cindy L. H. ;

Lau, Allan S. Y. .

ACS CHEMICAL NEUROSCIENCE, 2014, 5 (09) :855-866

[24] Obesity and nutrient sensing TOR pathway in flies and vertebrates: Functional conservation of genetic mechanisms [J].

Oldham, Sean .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2011, 22 (02) :45-52

[25] Activation of the STING-IRF3 pathway promotes hepatocyte inflammation, apoptosis and induces metabolic disorders in nonalcoholic fatty liver disease [J].

Qiao, J. T. ;

Cui, C. ;

Qing, L. ;

Wang, L. S. ;

He, T. Y. ;

Yan, F. ;

Liu, F. Q. ;

Shen, Y. H. ;

Hou, X. G. ;

Chen, L. .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2018, 81 :13-24

[26]

Saxton RA, 2017, CELL, V168, P960, DOI [10.1016/j.cell.2017.02.004, 10.1016/j.cell.2017.03.035]

[27] Chronic oxidative stress sensitizes hepatocytes to death from 4-hydroxynonenal by JNK/c-Jun overactivation [J].

Singh, Rajat ;

Wang, Yongjun ;

Schattenberg, Joern M. ;

Xiang, Youqing ;

Czaja, Mark J. .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2009, 297 (05) :G907-G917

[28] Rubicon Inhibits Autophagy and Accelerates Hepatocyte Apoptosis and Lipid Accumulation in Nonalcoholic Fatty Liver Disease in Mice [J].

Tanaka, Satoshi ;

Hikita, Hayato ;

Tatsumi, Tomohide ;

Sakamori, Ryotaro ;

Nozaki, Yasutoshi ;

Sakane, Sadatsugu ;

Shiode, Yuto ;

Nakabori, Tasuku ;

Saito, Yoshinobu ;

Hiramatsu, Naoki ;

Tabata, Keisuke ;

Kawabata, Tsuyoshi ;

Hamasaki, Maho ;

Eguchi, Hidetoshi ;

Nagano, Hiroaki ;

Yoshimori, Tamotsu ;

Takehara, Tetsuo .

HEPATOLOGY, 2016, 64 (06) :1994-2014

[29] Cyclophilin D deficiency attenuates mitochondrial perturbation and ameliorates hepatic steatosis [J].

Wang, Xiaolei ;

Du, Heng ;

Shao, Shanshan ;

Bo, Tao ;

Yu, Chunxiao ;

Chen, Wenbin ;

Zhao, Lifang ;

Li, Qiu ;

Wang, Li ;

Liu, Xiaojing ;

Su, Xiaohui ;

Sun, Mingqi ;

Song, Yongfeng ;

Gao, Ling ;

Zhao, Jiajun .

HEPATOLOGY, 2018, 68 (01) :62-77

← 1 2 3 →