The many faces of the anti-COVID immune response

被引：391

作者：

Vardhana, Santosha A. ^{[1
,2
,3
]}

Wolchok, Jedd D. ^{[3
,4
,5
,6
,7
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, 1275 York Ave, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Ctr Epigenet Res, 1275 York Ave, New York, NY 10021 USA

[3] Parker Inst Canc Immunotherapy, San Francisco, CA 94129 USA

[4] Mem Sloan Kettering Canc Ctr, Dept Med, Human Oncol Pathogenesis Program, 1275 York Ave, New York, NY 10021 USA

[5] Mem Sloan Kettering Canc Ctr, Ludwig Ctr, 1275 York Ave, New York, NY 10021 USA

[6] Weill Cornell Med, New York, NY USA

[7] Grad Sch Biomed Sci, New York, NY USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2020年 / 217卷 / 06期

关键词：

ACUTE RESPIRATORY SYNDROME; INFLUENZA-A H1N1; CD8; T-CELLS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; INTRAVENOUS N-ACETYLCYSTEINE; CLINICAL CHARACTERISTICS; ANTIVIRAL RESPONSES; CORONAVIRUS DISEASE; DOUBLE-BLIND; CYTOKINE;

D O I：

10.1084/jem.20200678

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The novel 2019 strain of coronavirus is a source of profound morbidity and mortality worldwide. Compared with recent viral outbreaks, COVID-19 infection has a relatively high mortality rate, the reasons for which are not entirely clear. Furthermore, treatment options for COVID-19 infection are currently limited. In this Perspective, we explore the contributions of the innate and adaptive immune systems to both viral control as well as toxicity during COVID-19 infections and offer suggestions to both understand and therapeutically modulate anti-COVID immunity.

引用

页数：10

共 100 条

[21] Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19) [J].

Diao, Bo ;

Wang, Chenhui ;

Tan, Yingjun ;

Chen, Xiewan ;

Liu, Ying ;

Ning, Lifen ;

Chen, Li ;

Li, Min ;

Liu, Yueping ;

Wang, Gang ;

Yuan, Zilin ;

Feng, Zeqing ;

Zhang, Yi ;

Wu, Yuzhang ;

Chen, Yongwen .

FRONTIERS IN IMMUNOLOGY, 2020, 11

[22] Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA [J].

Diebold, SS ;

Kaisho, T ;

Hemmi, H ;

Akira, S ;

Sousa, CRE .

SCIENCE, 2004, 303 (5663) :1529-1531

[23] Effectiveness of convalescent plasma therapy in severe COVID-19 patients [J].

Duan, Kai ;

Liu, Bende ;

Li, Cesheng ;

Zhang, Huajun ;

Yu, Ting ;

Qu, Jieming ;

Zhou, Min ;

Chen, Li ;

Meng, Shengli ;

Hu, Yong ;

Peng, Cheng ;

Yuan, Mingchao ;

Huang, Jinyan ;

Wang, Zejun ;

Yu, Jianhong ;

Gao, Xiaoxiao ;

Wang, Dan ;

Yu, Xiaoqi ;

Li, Li ;

Zhang, Jiayou ;

Wu, Xiao ;

Li, Bei ;

Xu, Yanping ;

Chen, Wei ;

Peng, Yan ;

Hu, Yeqin ;

Lin, Lianzhen ;

Liu, Xuefei ;

Huang, Shihe ;

Zhou, Zhijun ;

Zhang, Lianghao ;

Wang, Yue ;

Zhang, Zhi ;

Deng, Kun ;

Xia, Zhiwu ;

Gong, Qin ;

Zhang, Wei ;

Zheng, Xiaobei ;

Liu, Ying ;

Yang, Huichuan ;

Zhou, Dongbo ;

Yu, Ding ;

Hou, Jifeng ;

Shi, Zhengli ;

Chen, Saijuan ;

Chen, Zhu ;

Zhang, Xinxin ;

Yang, Xiaoming .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (17) :9490-9496

[24] Viral acute lower respiratory infections impair CD8+ T cells through PD-1 [J].

Erickson, John J. ;

Gilchuk, Pavlo ;

Hastings, Andrew K. ;

Tollefson, Sharon J. ;

Johnson, Monika ;

Downing, Melissa B. ;

Boyd, Kelli L. ;

Johnson, Joyce E. ;

Kim, Annette S. ;

Joyce, Sebastian ;

Williams, John V. .

JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (08) :2967-2982

[25] N-ACETYLCYSTEINE ENHANCES T-CELL FUNCTIONS AND T-CELL GROWTH IN CULTURE [J].

EYLAR, E ;

RIVERAQUINONES, C ;

MOLINA, C ;

BAEZ, I ;

MOLINA, F ;

MERCADO, CM .

INTERNATIONAL IMMUNOLOGY, 1993, 5 (01) :97-101

[26]

Feng Z., The Novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Directly Decimates Human Spleens and Lymph Nodes, P2020, DOI [10.1101/2020.03.27.20045427, DOI 10.1101/2020.03.27.20045427]

[27] Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B [J].

Fisicaro, Paola ;

Barili, Valeria ;

Montanini, Barbara ;

Acerbi, Greta ;

Ferracin, Manuela ;

Guerrieri, Francesca ;

Salerno, Debora ;

Boni, Carolina ;

Massari, Marco ;

Cavallo, M. Cristina ;

Grossi, Glenda ;

Giuberti, Tiziana ;

Lampertico, Pietro ;

Missale, Gabriele ;

Levrero, Massimo ;

Ottonello, Simone ;

Ferrari, Carlo .

NATURE MEDICINE, 2017, 23 (03) :327-336

[28] Cytokine and Chemokine Profiles in Lung Tissues from Fatal Cases of 2009 Pandemic Influenza A (H1N1) Role of the Host Immune Response in Pathogenesis [J].

Gao, Rongbao ;

Bhatnagar, Julu ;

Blau, Dianna M. ;

Greer, Patricia ;

Rollin, Dominique C. ;

Denison, Amy M. ;

Deleon-Carnes, Marlene ;

Shieh, Wun-Ju ;

Sambhara, Suryaprakash ;

Tumpey, Terrence M. ;

Patel, Mitesh ;

Liu, Lindy ;

Paddock, Christopher ;

Drew, Clifton ;

Shu, Yuelong ;

Katz, Jacqueline M. ;

Zaki, Sherif R. .

AMERICAN JOURNAL OF PATHOLOGY, 2013, 183 (04) :1258-1268

[29] Effect of the Novel Influenza A (H1N1) Virus in the Human Immune System [J].

Giamarellos-Bourboulis, Evangelos J. ;

Raftogiannis, Maria ;

Antonopoulou, Anastasia ;

Baziaka, Fotini ;

Koutoukas, Pantelis ;

Savva, Athina ;

Kanni, Theodora ;

Georgitsi, Marianna ;

Pistiki, Aikaterini ;

Tsaganos, Thomas ;

Pelekanos, Nikolaos ;

Athanassia, Sofia ;

Galani, Labrini ;

Giannitsioti, Efthymia ;

Kavatha, Dimitra ;

Kontopidou, Flora ;

Mouktaroudi, Maria ;

Poulakou, Garyfallia ;

Sakka, Vissaria ;

Panagopoulos, Periklis ;

Papadopoulos, Antonios ;

Kanellakopoulou, Kyriaki ;

Giamarellou, Helen .

PLOS ONE, 2009, 4 (12)

[30] CAR T cell-induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade [J].

Giavridis, Theodoros ;

van der Stegen, Sjoukje J. C. ;

Eyquem, Justin ;

Hamieh, Mohamad ;

Piersigilli, Alessandra ;

Sadelain, Michel .

NATURE MEDICINE, 2018, 24 (06) :731-+

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