The many faces of the anti-COVID immune response

被引：387
作者：
Vardhana, Santosha A. [1 ,2 ,3 ]
Wolchok, Jedd D. [3 ,4 ,5 ,6 ,7 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, 1275 York Ave, New York, NY 10021 USA
[2] Mem Sloan Kettering Canc Ctr, Ctr Epigenet Res, 1275 York Ave, New York, NY 10021 USA
[3] Parker Inst Canc Immunotherapy, San Francisco, CA 94129 USA
[4] Mem Sloan Kettering Canc Ctr, Dept Med, Human Oncol Pathogenesis Program, 1275 York Ave, New York, NY 10021 USA
[5] Mem Sloan Kettering Canc Ctr, Ludwig Ctr, 1275 York Ave, New York, NY 10021 USA
[6] Weill Cornell Med, New York, NY USA
[7] Grad Sch Biomed Sci, New York, NY USA
来源：
JOURNAL OF EXPERIMENTAL MEDICINE | 2020年 / 217卷 / 06期
关键词：
ACUTE RESPIRATORY SYNDROME; INFLUENZA-A H1N1; CD8; T-CELLS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; INTRAVENOUS N-ACETYLCYSTEINE; CLINICAL CHARACTERISTICS; ANTIVIRAL RESPONSES; CORONAVIRUS DISEASE; DOUBLE-BLIND; CYTOKINE;
D O I：
10.1084/jem.20200678
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The novel 2019 strain of coronavirus is a source of profound morbidity and mortality worldwide. Compared with recent viral outbreaks, COVID-19 infection has a relatively high mortality rate, the reasons for which are not entirely clear. Furthermore, treatment options for COVID-19 infection are currently limited. In this Perspective, we explore the contributions of the innate and adaptive immune systems to both viral control as well as toxicity during COVID-19 infections and offer suggestions to both understand and therapeutically modulate anti-COVID immunity.
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页数：10
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