Anticancer polysaccharides from natural resources: A review of recent research

被引：534

作者：

Zong, Aizhen ^{[2
]}

Cao, Hongzhi ^{[1
]}

Wang, Fengshan ^{[1
,2
]}

机构：

[1] Shandong Univ, Natl Glycoengn Res Ctr, Jinan 250012, Shandong, Peoples R China

[2] Shandong Univ, Sch Pharmaceut Sci, Key Lab Chem Biol, Inst Biochem & Biotechnol Drugs,Minist Educ, Jinan 250012, Shandong, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2012年 / 90卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Polysaccharides; Polysaccharide-protein complexes; Anticancer; PROTEIN-BOUND POLYSACCHARIDE; GANODERMA-LUCIDUM POLYSACCHARIDES; SUPERFINE DISPERSED LENTINAN; ACTIVITIES IN-VITRO; GEKKO SULFATED POLYSACCHARIDE; MOLECULAR-WEIGHT POLYSACCHARIDE; LYCIUM-BARBARUM POLYSACCHARIDES; WATER-SOLUBLE POLYSACCHARIDES; PECTIN INDUCES APOPTOSIS; MELANOMA-CELL METASTASIS;

D O I：

10.1016/j.carbpol.2012.07.026

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Taking into account the rising trend of the incidence of cancers of various organs, effective therapies are urgently needed to control human malignancies. However, almost all of the chemotherapy drugs currently on the market cause serious side effects. Fortunately, several previous studies have shown that some non-toxic biological macromolecules, including polysaccharides and polysaccharide-protein complexes, possess anti-cancer activities or can increase the efficacy of conventional chemotherapy drugs. Based on these encouraging observations, a great deal of effort has been focused on discovering anticancer polysaccharides and complexes for the development of effective therapeutics for various human cancers. This review focuses on the advancements in the anti-cancer efficacy of various natural polysaccharides and polysaccharide complexes in the past 5 years. Most polysaccharides were tested using model systems, while several involved clinical trials. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1395 / 1410

页数：16

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