Enantioselective construction of spiro-1,3-indandiones with three stereocenters via organocatalytic Michael-aldol reaction of 2-arylideneindane-1,3-diones and nitro aldehydes

被引：32

作者：

Duan, Jindian ^{[1
]}

Cheng, Jing ^{[1
]}

Li, Pengfei ^{[1
]}

机构：

[1] South Univ Sci & Technol China, Dept Chem, Shenzhen 518055, Guangdong, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2015年 / 2卷 / 09期

基金：

中国国家自然科学基金;

关键词：

1,3-DIPOLAR CYCLOADDITION REACTION; MULTICOMPONENT REACTIONS; ASYMMETRIC CATALYSIS; DOMINO REACTIONS; DIELS-ALDER; SUBSTITUTED DISPIROCYCLOHEXANES; DIASTEREOSELECTIVE SYNTHESIS; ANNULATION STRATEGY; CASCADE REACTIONS; DRUG DISCOVERY;

D O I：

10.1039/c5qo00166h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric domino reaction between 2-arylideneindane-1,3-dione and nitro aldehyde has been developed for the construction of an enantioenriched spiro-1,3-indandione framework with three stereocenters. In the presence of a squaramide-tertiary amine, chiral spiro-1,3-indandione derivatives are obtained in good yields with high enantioselectivities and diastereoselectivities.

引用

页码：1048 / 1052

页数：5

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