Proliferation control in neural stem and progenitor cells

被引：263

作者：

Homem, Catarina C. F. ^{[1
]}

Repic, Marko ^{[1
]}

Knoblich, Juergen A. ^{[1
]}

机构：

[1] Inst Mol Biotechnol, A-1030 Vienna, Austria

来源：

NATURE REVIEWS NEUROSCIENCE | 2015年 / 16卷 / 11期

基金：

欧洲研究理事会; 奥地利科学基金会;

关键词：

OUTER SUBVENTRICULAR ZONE; CENTRAL-NERVOUS-SYSTEM; MAMMALIAN CEREBRAL-CORTEX; REGULATES SELF-RENEWAL; RADIAL GLIAL-CELLS; DROSOPHILA NEUROBLASTS; ASYMMETRIC DIVISION; CORTICAL NEUROGENESIS; DEVELOPING NEOCORTEX; BRAIN-DEVELOPMENT;

D O I：

10.1038/nrn4021

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neural circuit function can be drastically affected by variations in the number of cells that are produced during development or by a reduction in adult cell number owing to disease. For this reason, unique cell cycle and cell growth control mechanisms operate in the developing and adult brain. In Drosophila melanogaster and in mammalian neural stem and progenitor cells, these mechanisms are intricately coordinated with the developmental age and the nutritional, metabolic and hormonal state of the animal. Defects in neural stem cell proliferation that result in the generation of incorrect cell numbers or defects in neural stem cell differentiation can cause microcephaly or megalencephaly.

引用

收藏

页码：647 / 659

页数：13

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