Actinic Keratoses, Actinic Field Change and Associations with Squamous Cell Carcinoma in Renal Transplant Recipients in Manchester, UK

被引：28

作者：

Wallingford, Sarah C. ^{[1
]}

Russell, Sheila A. ^{[2
]}

Vail, Andy ^{[3
]}

Proby, Charlotte M. ^{[4
]}

Lear, John T. ^{[1
,5
]}

Green, Adele C. ^{[1
,6
]}

机构：

[1] Univ Manchester, Manchester Acad Hlth Sci Ctr, Inst Inflammat & Repair, Manchester M20 4BX, Lancs, England

[2] Manchester Royal Infirm, Kidney & Pancreas Transplant Unit, Manchester M13 9WL, Lancs, England

[3] Univ Manchester, Manchester Acad Hlth Sci Ctr, Salford Royal Hosp, Ctr Biostat, Salford, Lancs, England

[4] Univ Dundee, Ninewells Hosp & Med Sch, Med Res Inst, Div Canc Res, Dundee DD1 9SY, Scotland

[5] Manchester Royal Infirm, Dept Dermatol, Manchester M13 9WL, Lancs, England

[6] QIMR Berghofer Med Res Inst, Canc & Populat Studies Grp, Brisbane, Qld, Australia

来源：

ACTA DERMATO-VENEREOLOGICA | 2015年 / 95卷 / 07期

基金：

英国医学研究理事会;

关键词：

actinic keratosis; actinic field change; renal transplant recipients; squamous cell carcinoma; immunosuppression; NONMELANOMA SKIN-CANCER; RISK-FACTORS; CANCERIZATION; EPIDEMIOLOGY; LESIONS;

D O I：

10.2340/00015555-2098

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

While actinic keratoses (AKs) have a known association with cutaneous squamous cell carcinoma (SCC), the relation of actinic field change to SCC has not been quantified. This study investigated the presence of field change and AKs in renal transplant recipients (RTRs) and estimated SCC risk. In May 2010 to October 2011, a dermatologist examined 452 white RTRs (mean age 53 years) at two hospitals in Manchester, UK, counting AKs and recording field change presence by body site and SCCs arising during the study period. Of the participants 130 (29%) had AKs at examination. In 60 (13%) RTR patients with AKs but no field change, 4 (7%) developed SCCs, compared with 15 (21%) of the 70 (15%) with AKs and field change. SCCs developed directly within field change areas in 11/15 (73%) RTRs. This study confirms that RTRs with widespread confluent actinic skin damage are at very high risk of SCC and should be monitored closely.

引用

页码：830 / 834

页数：5

共 26 条

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