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Voluntary Physical Exercise Improves Subsequent Motor and Cognitive Impairments in a Rat Model of Parkinson's Disease
被引:44
作者:
Hsueh, Shih-Chang
[1
,2
]
Chen, Kai-Yun
[1
,2
]
Lai, Jing-Huei
[2
,3
]
Wu, Chung-Che
[1
,2
,3
,4
]
Yu, Yu-Wen
[1
,2
]
Luo, Yu
[5
]
Hsieh, Tsung-Hsun
[1
,2
,6
,7
]
Chiang, Yung-Hsiao
[1
,2
,3
,4
]
机构:
[1] Taipei Med Univ, Coll Med Sci & Technol, PhD Program Neural Regenerat Med, Taipei 11031, Taiwan
[2] Taipei Med Univ, Ctr Neurotrauma & Neuroregenerat, Taipei 11031, Taiwan
[3] Taipei Med Univ, Sch Med, Dept Surg, Coll Med, Taipei 11031, Taiwan
[4] Taipei Med Univ Hosp, Dept Neurosurg, Taipei 11031, Taiwan
[5] Case Western Reserve Univ, Sch Med, Dept Neurosurg, Cleveland, OH 44106 USA
[6] Chang Gung Univ, Dept Phys Therapy, Coll Med, Taoyuan 33302, Taiwan
[7] Chang Gung Univ, Grad Inst Rehabil Sci, Coll Med, Taoyuan 33302, Taiwan
关键词:
voluntary physical exercise;
Parkinson's disease;
6-hydroxydopamine;
neuroprotection;
TYROSINE KINASE;
HEMIPARKINSONIAN RATS;
DEPRESSIVE SYMPTOMS;
STRIDE LENGTH;
CANCER CELLS;
GAIT;
ETK/BMX;
MEMORY;
BRAIN;
6-HYDROXYDOPAMINE;
D O I:
10.3390/ijms19020508
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Background: Parkinson's disease (PD) is typically characterized by impairment of motor function. Gait disturbances similar to those observed in patients with PD can be observed in animals after injection of neurotoxin 6-hydroxydopamine (6-OHDA) to induce unilateral nigrostriatal dopamine depletion. Exercise has been shown to be a promising non-pharmacological approach to reduce the risk of neurodegenerative disease. Methods: In this study, we investigated the long-term effects of voluntary running wheel exercise on gait phenotypes, depression, cognitive, rotational behaviors as well as histology in a 6-OHDA-lesioned rat model of PD. Results: We observed that, when compared with the non-exercise controls, five-week voluntary exercise alleviated and postponed the 6-OHDA-induced gait deficits, including a significantly improved walking speed, step/stride length, base of support and print length. In addition, we found that the non-motor functions, such as novel object recognition and forced swim test, were also ameliorated by voluntary exercise. However, the rotational behavior of the exercise group did not show significant differences when compared with the non-exercise group. Conclusions: We first analyzed the detailed spatiotemporal changes of gait pattern to investigate the potential benefits after long-term exercise in the rat model of PD, which could be useful for future objective assessment of locomotor function in PD or other neurological animal models. Furthermore, these results suggest that short-term voluntary exercise is sufficient to alleviate cognition deficits and depressive behavior in 6-OHDA lesioned rats and long-term treatment reduces the progression of motor symptoms and elevates tyrosine hydroxylase (TH), Brain-derived neurotrophic factor (BDNF), bone marrow tyrosine kinase in chromosome X (BMX) protein expression level without affecting dopaminergic (DA) neuron loss in this PD rat model.
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