In vivo intra- and inter -individual variability study of human stratum corneum by confocal Raman spectroscopy

被引：0

作者：

dos Santos, Laurita ^{[1
]}

Rangel, Joao Lucas ^{[1
]}

Tippavajhala, Vamshi Krishna ^{[1
,2
]}

Pereira da Silva, Michely Glenda ^{[1
]}

Mogilevych, Borys ^{[1
]}

Martin, Airton Abrahao ^{[1
]}

机构：

[1] Univ Vale Paraiba UNIVAP, Res & Dev Inst IP&D, Lab Biomed Vibrat Spect LEVB, Av Shishima Hifumi 2911, BR-12244000 Sao Jose Dos Campos, SP, Brazil

[2] Manipal Univ, Manipal Coll Pharmaceut Sci, Dept Pharmaceut, Manipal, Karnataka, India

来源：

VIBRATIONAL SPECTROSCOPY | 2016年 / 87卷

关键词：

In vivo human skin variability; Intra; and inter-individual variability; Confocal Raman spectroscopy; HUMAN SKIN; BARRIER FUNCTION; EPIDERMIS; DELIVERY; PENETRATION; BIOANALYSIS; SYSTEM; VITRO; ACIDS;

D O I：

10.1016/j.vibspec.2016.10.007

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The present research work deals with the in vivo determination of intra- and inter-individual human stratum corneum biochemical variability using confocal Raman spectroscopy. This study was carried out at three different spots on the volar forearm region of healthy human participants in the extended fingerprint and high wavenumber spectral regions. All the preprocessed spectra were compared by correlation matrices, which were calculated using Pearson's correlation coefficient (r). The results indicate that the participated volunteers in this study are homogenous with respect to the stratum corneum in the forearm region in both extended fingerprint and high wavenumber regions as there is high correlation between their Raman spectra at both intra- and inter-individual levels. This study confirms the application of confocal Raman spectroscopy as an accurate and precise technique for in vivo studies involving human skin. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：199 / 206

页数：8

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