Efficacy of simultaneous VEGF-A/ANG-2 neutralization in suppressing spontaneous choroidal neovascularization

被引：56

作者：

Foxton, Richard H. ^{[1
]}

Uhles, Sabine ^{[1
]}

Gruner, Sabine ^{[1
]}

Revelant, Franco ^{[1
]}

Ullmer, Christoph ^{[1
]}

机构：

[1] F Hoffmann La Roche Ltd, Roche Innovat Ctr Basel, Pharma Res & Early Dev, Ophthalmol Discovery, Basel, Switzerland

来源：

EMBO MOLECULAR MEDICINE | 2019年 / 11卷 / 05期

关键词：

VEGF-A; CROSSMAB; GROWTH; EDEMA;

D O I：

10.15252/emmm.201810204

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

This study independently confirms in vivo in the JR5558 mouse model of aberrant retinal angiogenesis, that simultaneous VEGF-A and ANG-2 neutralization using a bispecific anti-VEGF-A/ANG-2 antibody reduces vascular leakage, immune reactivity and apoptosis more effectively than either agent alone.

引用

页数：6

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