Leptin promotes lupus T-cell autoimmunity

被引：45
作者：
Amarilyo, Gil [1 ]
Iikuni, Noriko [1 ]
Shi, Fu-Dong [2 ]
Liu, Aijing [1 ]
Matarese, Giuseppe [3 ,4 ,5 ]
La Cava, Antonio [1 ]
机构：
[1] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90095 USA
[2] Barrow Neurol Inst, Phoenix, AZ 85013 USA
[3] Univ Salerno, Fac Med & Chirurg, I-84081 Baronissi, Italy
[4] IEOS CNR, Naples, Italy
[5] IRCCS MultiMed, Milan, Italy
来源：
CLINICAL IMMUNOLOGY | 2013年 / 149卷 / 03期
关键词：
Apoptosis; Systemic lupus erythematosus; Autoreactive T cells; Autoimmunity; SERUM LEPTIN; ERYTHEMATOSUS; WOMEN; DNA;
D O I：
10.1016/j.clim.2013.09.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In systemic lupus erythematosus (SLE), the impairment in apoptosis can facilitate the initiation and maintenance of autoimmune responses to self antigens. Here we show that the adipocytokine leptin, which is abnormally elevated in SLE, promotes the survival and proliferation of autoreactive T-cells in mice with an autoreactive T-cell repertoire, including (NZB x NZW)F-1 lupus-prone mice. This ability of leptin to promote lupus T-cell autoimmunity suggests the possibility of a therapeutic targeting of leptin in SLE. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码：530 / 533
页数：4
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