Total Synthesis and Biological Evaluation of Jerantinine E

被引：47

作者：

Frei, Reto ^{[1
]}

Staedler, Davide ^{[3
]}

Raja, Aruna ^{[2
]}

Franke, Raimo ^{[2
]}

Sasse, Florenz ^{[2
]}

Gerber-Lemaire, Sandrine ^{[3
]}

Waser, Jerome ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Lab Catalysis & Organ Synth, EPFL SB ISIC LCSO, CH-1015 Lausanne, Switzerland

[2] Helmholtz Ctr Infect Res, Dept Biol Chem, D-38124 Braunschweig, Germany

[3] Ecole Polytech Fed Lausanne, Lab Synth & Nat Prod, EPFL SB ISIC LSPN, CH-1015 Lausanne, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 50期

关键词：

alkaloids; cancer; indoles; natural products; total synthesis; ASPIDOSPERMA ALKALOIDS; DL-ASPIDOSPERMIDINE; QUEBRACHAMINE; CYCLIZATION; (+)-ASPIDOSPERMIDINE; AMINOCYCLOPROPANES; (-)-VINDOLINE; VINBLASTINE; VINDOLINE; MECHANISM;

D O I：

10.1002/anie.201305533

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nature's beauty: The first total synthesis of the alkaloid natural product jerantinineE is based on a selective cyclization of an aminocyclopropane. Preliminary investigations show that it inhibits the polymerization of tubulin, displaying significant cytotoxicity and antimigratory activity against both breast and lung cancer cell lines. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：13373 / 13376

页数：4

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