EZH2: Its regulation and roles in immune disturbance of SLE

被引：12

作者：

Yang, Yiying ^{[1
,2
,3
]}

Liu, Ke ^{[2
,3
]}

Liu, Meidong ^{[2
,3
]}

Zhang, Huali ^{[1
,2
,3
]}

Guo, Muyao ^{[1
,4
,5
]}

机构：

[1] Cent South Univ, Xiangya Hosp, Dept Rheumatol, Changsha, Peoples R China

[2] Cent South Univ, Sch Basic Med Sci, Dept Pathophysiol, Changsha, Peoples R China

[3] Sepsis Translat Med Key Lab Hunan Prov, Changsha, Peoples R China

[4] Xiangya Hosp, Prov Clin Res Ctr Rheumat & Immunol Dis, Changsha, Peoples R China

[5] Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2022年 / 13卷

基金：

中国国家自然科学基金;

关键词：

EZH2; systemic lupus erythematosus; T cells; B cells; immune homeostasis; SYSTEMIC-LUPUS-ERYTHEMATOSUS; GROUP PROTEIN EZH2; HISTONE MODIFICATION PATTERNS; GERMINAL CENTER FORMATION; DNA METHYLATION; T-CELLS; METHYLTRANSFERASE ACTIVITY; NONCANONICAL FUNCTION; BREAST-CANCER; CHIP-CHIP;

D O I：

10.3389/fphar.2022.1002741

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The pathogenesis of systemic lupus erythematosus (SLE) is related to immune homeostasis imbalance. Epigenetic mechanisms have played a significant role in breaking immune tolerance. Enhancer of zeste homolog 2 (EZH2), the specific methylation transferase of lysine at position 27 of histone 3, is currently found to participate in the pathogenesis of SLE through affecting multiple components of the immune system. This review mainly expounds the mechanisms underlying EZH2-mediated disruption of immune homeostasis in SLE patients, hoping to provide new ideas in the pathogenesis of SLE and new targets for future treatment.

引用

页数：14

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