Safety, Feasibility, and Efficacy of Capecitabine Maintenance in Patients With Advanced Gastric Cancer: A Retrospective Study

被引：12
作者：
Eren, Orhan Onder [1 ]
Ozturk, Mehmet Akif [2 ]
Sonmez, Ozlem Uysal [1 ]
Oyan, Basak [1 ]
机构：
[1] Yeditepe Univ Hosp, Dept Clin Oncol, Istanbul, Turkey
[2] Yeditepe Univ Hosp, Dept Internal Med, Istanbul, Turkey
来源：
AMERICAN JOURNAL OF THERAPEUTICS | 2016年 / 23卷 / 06期
关键词：
gastric; cancer; maintenance; capecitabine; PHASE-III; 1ST-LINE CHEMOTHERAPY; PLUS CAPECITABINE; CISPLATIN; THERAPY; OXALIPLATIN; FLUOROURACIL; METAANALYSIS; MULTICENTER; IRINOTECAN;
D O I：
10.1097/MJT.0000000000000156
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Gastric cancer is still one of the cancers with highest mortality. Most patients present with advanced-stage disease. Palliative chemotherapy is usually the only treatment option for patients with advanced gastric cancer (AGC). Maintenance chemotherapy is an evolving concept in medical oncology. Maintenance chemotherapy can be administered with the same drug(s) in the initial regimen or with an alternative agent. In this article, we report our experience with capecitabine as a maintenance agent for patients with AGC. No treatment-related death was observed due to use of capecitabine. Median progression-free survival was 10.4 months, and median overall survival was 19.7 months. Activity and toxicity profile of capecitabine seems favorable as a maintenance agent in AGC. We believe that capecitabine deserves further trials as a maintenance agent for patients with AGC.
引用
收藏
页码：E1493 / E1497
页数：5
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