Pentacyclic triterpenes. Part 2: Synthesis and biological evaluation of maslinic acid derivatives as glycogen phosphorylase inhibitors

被引：95

作者：

Wen, XA

Zhang, P

Liu, J

Zhang, LY

Wu, XM

Ni, PZ

Sun, HB

机构：

[1] China Pharmaceut Univ, Coll Pharm, Dept Med Chem, Nanjing 210009, Peoples R China

[2] China Pharmaceut Univ, Jiangsu Ctr Drug Screening, Nanjing 210038, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 03期

关键词：

glycogen phosphorylase; inhibitor; maslinic acid; derivatives; synthesis; SAR;

D O I：

10.1016/j.bmcl.2005.10.014

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a series of maslinic acid derivatives is described and their effect on rabbit muscle glycogen phosphorylase a evaluated. Within this series of compounds, 15 (IC50 = 7 mu M) is the most potent GPa inhibitor. SAR of the maslinic acid derivatives are discussed. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：722 / 726

页数：5

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