Recent progress of micro-needle formulations: Fabrication strategies and delivery applications

被引：22

作者：

Cheng, Huiling ^{[1
]}

Liu, Mengrui ^{[1
]}

Du, Xiyou ^{[1
]}

Xu, Jiangkang ^{[1
]}

Zhai, Yujia ^{[2
]}

Ji, Jianbo ^{[1
]}

He, Shuwang ^{[1
,3
,4
]}

Zhai, Guangxi ^{[1
,4
]}

机构：

[1] Shandong Univ, Coll Pharm, Dept Pharmaceut, 44 Wenhua Xilu, Jinan 250012, Shandong, Peoples R China

[2] China Pharmaceut Univ, Coll Pharm, Nanjing 210009, Jiangsu, Peoples R China

[3] Shandong Dyne Marine Biopharmaceut Ltd Corp, Dept Pharmaceut Dev, 19 Lingming Beilu, Rongcheng 264300, Peoples R China

[4] Pediat Pharmaceut Preparat Engn Lab Shandong Prov, Rongcheng 264300, Peoples R China

来源：

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2019年 / 50卷

关键词：

Micro-needle; Etching; Transdermal drug delivery; Biopharmaceuticals; TRANSDERMAL DELIVERY; MICRONEEDLE ARRAYS; IN-VITRO; MICROFABRICATED MICRONEEDLES; DISSOLVING MICRONEEDLES; INTRADERMAL INJECTION; BIODEGRADABLE POLYMER; PULMONARY ABSORPTION; DRUG-DELIVERY; SKIN;

D O I：

10.1016/j.jddst.2019.01.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Micro-needle (MN), a kind of micro-device, has been proposed to act as drug delivery systems since 1990s. It can be made from silicon, metal, polymer and ceramic materials. A broad range of biopharmaceuticals are delivered by MN into skin, especially the supra-molecule which can not get through the stratum corneum. MN causes less pain and increases drug absorption by orders of magnitude compared to hypodermic syringe. Several published articles in a decade have been reported, demonstrating a great progress in the design, manufacture and application of MN. This review spotlights the fabrication materials of MN, preparation methods and delivery applications of MN in human diseases. Potential safety aspects in this transdermal drug delivery systems are also described in detail.

引用

页码：18 / 26

页数：9

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