Combined mTOR inhibition and autophagy inhibition: Phase I trial of temsirolimus and hydroxchloroquine in patients with advanced solid tumors

被引：0

作者：

Algazy, Kenneth M. ^{[1
]}

Schuchter, Lynn M. ^{[1
]}

Demichele, Angela M. ^{[1
]}

David, Vaughn J. ^{[1
]}

Torigian, Drew A. ^{[1
]}

Chang, Claire Y. ^{[1
]}

Redlinger, Maryann ^{[1
]}

Davis, Lisa E. ^{[1
]}

O'Dwyer, Peter J. ^{[1
]}

Amaravadi, Ravi K. ^{[1
]}

机构：

[1] Univ Penn, Philadelphia, PA 19104 USA

来源：

CANCER RESEARCH | 2011年 / 71卷

关键词：

D O I：

10.1158/1538-7445.AM2011-4500

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

4500

引用

页数：1

共 50 条

[21] A phase Ib trial of ERK inhibition with ulixertinib combined with palbociclib in patients (Pts) with advanced solid tumors. [J].

Raybould, Alison L. ;

Burgess, Brian ;

Urban, Clarissa ;

Naim, Rashid ;

Lee, Michael Sangmin ;

McRee, Autumn Jackson .

JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (15)

[22] Phase I-II Trial of Combined PKC Iota and mTOR Inhibition for Patients with Advanced or Recurrent Lung Cancer - A Trial in Progress [J].

Ross, Helen J. ;

Paripati, Harshita ;

Justilien, Verline ;

Fields, Alan .

JOURNAL OF THORACIC ONCOLOGY, 2015, 10 (09) :S663-S663

[23] Phase I study of temsirolimus in combination with cetuximab in patients with advanced solid tumors. [J].

Hollebecque, Antoine ;

Bahleda, Rastislav ;

Thery, Jean Christophe ;

Faivre, Laura ;

Le Deley, Marie-Cecile ;

Paci, Angelo ;

Varga, Andrea ;

Gazzah, Anas ;

Massard, Christophe ;

Poinsignon, Vianney ;

Malekzadeh, Katty ;

Ribrag, Vincent ;

Angevin, Eric ;

Postel-Vinay, Sophie ;

Gomez-Roca, Carlos Alberto ;

Gharib, Myriam ;

Dufour, Fabienne ;

Soria, Jean-Charles ;

Spano, Jean-Philippe .

JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)

[24] Autophagy Inhibition to Augment mTOR Inhibition: a Phase I/II Trial of Everolimus and Hydroxychloroquine in Patients with Previously Treated Renal Cell Carcinoma [J].

Haas, Naomi B. ;

Appleman, Leonard J. ;

Stein, Mark ;

Redlinger, Maryann ;

Wilks, Melissa ;

Xu, Xiaowei ;

Onorati, Angelique ;

Kalavacharla, Anusha ;

Kim, Taehyong ;

Zhen, Chao Jie ;

Kadri, Sabah ;

Segal, Jeremy P. ;

Gimotty, Phyllis A. ;

Davis, Lisa E. ;

Amaravadi, Ravi K. .

CLINICAL CANCER RESEARCH, 2019, 25 (07) :2080-2087

[25] Combined autophagy and HDAC inhibition A phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of hydroxychloroquine in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumors [J].

Mahalingam, Devalingam ;

Mita, Monica ;

Sarantopoulos, John ;

Wood, Leslie ;

Amaravadi, Ravi K. ;

Davis, Lisa E. ;

Mita, Alain ;

Curiel, Tyler J. ;

Espitia, Claudia M. ;

Nawrocki, Steffan T. ;

Giles, Francis J. ;

Carew, Jennifer S. .

AUTOPHAGY, 2014, 10 (08) :1403-1414

[26] Phase I study of the combination of temsirolimus and pazopanib in advanced solid tumors [J].

Semrad, Thomas J. ;

Eddings, Courtney ;

Dutia, Mrinal P. ;

Christensen, Scott ;

Lara, Primo N. .

ANTI-CANCER DRUGS, 2013, 24 (06) :636-640

[27] Dual inhibition of VEGF pathway: Phase I trial of bevacizumab and cediranib in advanced solid tumors. [J].

Garrido-Laguna, I. ;

Kurzrock, R. ;

Wheler, J. J. ;

Falchook, G. S. ;

Piha-Paul, S. A. ;

Fu, S. ;

Naing, A. ;

Hinojosa, C. ;

Mistry, R. ;

Scamardo, A. ;

Culotta, K. S. ;

Ekmekcioglu, S. ;

Wen, S. ;

Camacho, L. H. ;

Ivy, S. P. ;

Hong, D. S. .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (15)

[28] Inhibition of autophagy: Phase I safety, tolerability, and pharmacokinetics (PK) of hydroxychloroquine (H) in combination with vorinostat (V) in patients with advanced solid tumors [J].

Mahalingam, Devalingam ;

Mita, Monica M. ;

Sarantopoulos, John ;

Wood, Leslie ;

Mita, Alain C. ;

Curiel, Tyler J. ;

Argiris, Athanassios ;

Nawrocki, Steffan T. ;

Carew, Jennifer S. ;

Giles, Francis J. .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (15)

[29] Combination mTOR plus IGF-IR inhibition: Phase I trial of everolimus and CP-751871 in patients (pts) with advanced sarcomas and other solid tumors [J].

Quek, R. H. ;

Morgan, J. A. ;

Shapiro, G. ;

Butrynski, J. E. ;

Wang, Q. ;

Huftalen, T. ;

Jederlinic, N. ;

Wagner, A. J. ;

Demetri, G. D. ;

George, S. .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (15)

[30] Phase I study of temsirolimus in combination with EKB-569 in patients with advanced solid tumors [J].

Alan H. Bryce ;

Ravi Rao ;

Jann Sarkaria ;

Joel M. Reid ;

Yingwei Qi ;

Rui Qin ;

C. David James ;

Robert B. Jenkins ;

Joseph Boni ;

Charles Erlichman ;

Paul Haluska .

Investigational New Drugs, 2012, 30 :1934-1941

← 1 2 3 4 5 →