Combined mTOR inhibition and autophagy inhibition: Phase I trial of temsirolimus and hydroxchloroquine in patients with advanced solid tumors

被引：0
|
作者：
Algazy, Kenneth M. [1 ]
Schuchter, Lynn M. [1 ]
Demichele, Angela M. [1 ]
David, Vaughn J. [1 ]
Torigian, Drew A. [1 ]
Chang, Claire Y. [1 ]
Redlinger, Maryann [1 ]
Davis, Lisa E. [1 ]
O'Dwyer, Peter J. [1 ]
Amaravadi, Ravi K. [1 ]
机构：
[1] Univ Penn, Philadelphia, PA 19104 USA
来源：
CANCER RESEARCH | 2011年 / 71卷
关键词：
D O I：
10.1158/1538-7445.AM2011-4500
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
4500
引用
收藏
页数：1
相关论文
共 50 条
  • [1] Combined MTOR and autophagy inhibition Phase I trial of hydroxychloroquine and temsirolimus in patients with advanced solid tumors and melanoma
    Rangwala, Reshma
    Chang, Yunyoung C.
    Hu, Janice
    Algazy, Kenneth
    Evans, Tracey
    Fecher, Leslie
    Schuchter, Lynn
    Torigian, Drew A.
    Panosian, Jeffrey
    Troxel, Andrea
    Tan, Kay-See
    Heitjan, Daniel F.
    Demichele, Angela
    Vaughn, David
    Redlinger, Maryann
    Alavi, Abass
    Kaiser, Jonathon
    Pontiggia, Laura
    Davis, Lisa E.
    O'Dwyer, Peter J.
    Amaravadi, Ravi K.
    AUTOPHAGY, 2014, 10 (08) : 1391 - 1402
  • [2] Combining chemotherapy with autophagy inhibition: Phase I trial of dose-intense temozolomide and hydroxchloroquine in patients with advanced solid tumors
    Fecher, Leslie A.
    Schuchter, Lynn M.
    Evans, Tracey
    Chang, Claire Y.
    Gallagher, Maryann
    Kramer, Amy
    O'Dwyer, Peter J.
    Amaravadi, Ravi K.
    CANCER RESEARCH, 2011, 71
  • [3] Phase I trial of MEK 1/2 inhibitor pimasertib combined with mTOR inhibitor temsirolimus in patients with advanced solid tumors
    Mita, Monica
    Fu, Siqing
    Piha-Paul, Sarina Anne
    Janku, Filip
    Mita, Alain
    Natale, Ronald
    Guo, Wei
    Zhao, Charles
    Kurzrock, Razelle
    Naing, Aung
    INVESTIGATIONAL NEW DRUGS, 2017, 35 (05) : 616 - 626
  • [4] Phase I trial of MEK 1/2 inhibitor pimasertib combined with mTOR inhibitor temsirolimus in patients with advanced solid tumors
    Monica Mita
    Siqing Fu
    Sarina Anne Piha-Paul
    Filip Janku
    Alain Mita
    Ronald Natale
    Wei Guo
    Charles Zhao
    Razelle Kurzrock
    Aung Naing
    Investigational New Drugs, 2017, 35 : 616 - 626
  • [5] Phase I clinical trial of temsirolimus and vinorelbine in advanced solid tumors
    Caroline I. Piatek
    Grace L. Raja
    Lingyun Ji
    Barbara Jennifer Gitlitz
    Tanya B. Dorff
    David I. Quinn
    James Hu
    Anthony B. El-Khoueiry
    Huyen Q. Pham
    Lynda Roman
    Agustin A. Garcia
    Cancer Chemotherapy and Pharmacology, 2014, 74 : 1227 - 1234
  • [6] PHASE I TRIAL OF CARBOPLATIN, BEVACIZUMAB, AND TEMSIROLIMUS IN ADVANCED SOLID TUMORS
    Westin, S.
    Castaneda, M.
    Pal, N.
    Urbauer, D.
    Janku, F.
    Wheler, J.
    Piha-Paul, S.
    Naing, A.
    Tsimberidou, A.
    Fu, S.
    Hong, D.
    Subbiah, V.
    Zinner, R.
    Karp, D.
    Coleman, R.
    Moulder, S.
    Kurzrock, R.
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2015, 25 (09) : 365 - 365
  • [7] Phase I clinical trial of temsirolimus and vinorelbine in advanced solid tumors
    Piatek, Caroline I.
    Raja, Grace L.
    Ji, Lingyun
    Gitlitz, Barbara Jennifer
    Dorff, Tanya B.
    Quinn, David I.
    Hu, James
    El-Khoueiry, Anthony B.
    Pham, Huyen Q.
    Roman, Lynda
    Garcia, Agustin A.
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2014, 74 (06) : 1227 - 1234
  • [8] Phase I trial of sorafenib, bevacizumab, and temsirolimus in advanced solid tumors.
    Westin, Shannon Neville
    Smart, Melody L.
    Pal, Navdeep
    Urbauer, Diana L.
    Janku, Filip
    Wheler, Jennifer J.
    Piha-Paul, Sarina Anne
    Naing, Aung
    Tsimberidou, Apostolia Maria
    Fu, Siqing
    Falchook, Gerald Steven
    Hong, David S.
    Zinner, Ralph
    Subbiah, Vivek
    Culotta, Kirk Salvatore
    Lu, Karen H.
    Coleman, Robert L.
    Kurzrock, Razelle
    JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (15)
  • [9] A phase I trial of temsirolimus and erlotinib in patients with refractory solid tumors
    Haeseong Park
    Kerry Williams
    Nikolaos A. Trikalinos
    Sarah Larson
    Benjamin Tan
    Saiama Waqar
    Rama Suresh
    Daniel Morgensztern
    Brian A. Van Tine
    Ramaswamy Govindan
    Jingqin Luo
    A. Craig Lockhart
    Andrea Wang-Gillam
    Cancer Chemotherapy and Pharmacology, 2021, 87 : 337 - 347
  • [10] A phase I trial of temsirolimus and erlotinib in patients with refractory solid tumors
    Park, Haeseong
    Williams, Kerry
    Trikalinos, Nikolaos A.
    Larson, Sarah
    Tan, Benjamin
    Waqar, Saiama
    Suresh, Rama
    Morgensztern, Daniel
    Van Tine, Brian A.
    Govindan, Ramaswamy
    Luo, Jingqin
    Lockhart, A. Craig
    Wang-Gillam, Andrea
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2021, 87 (03) : 337 - 347
12345