Hyaluronan oligosaccharides as a potential anticancer therapeutic

被引：76

作者：

Toole, Bryan P. ^{[1
]}

Ghatak, Shibnath ^{[1
]}

Misra, Suniti ^{[1
]}

机构：

[1] Med Univ S Carolina, Dept Cell Biol & Anat, Charleston, SC 29425 USA

来源：

CURRENT PHARMACEUTICAL BIOTECHNOLOGY | 2008年 / 9卷 / 04期

关键词：

cancer; metastasis; CD44; signaling; apoptosis;

D O I：

10.2174/138920108785161569

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hyaluronan (HA) polysaccharide has differential effects on cells depending on polymer size. One of the more exciting findings is that small chains or oligosaccharides of HA (6-18 sugar units), but not large polymers, will kill many types of cancer cells by triggering apoptosis while leaving normal cells unaffected. Even chemoresistant cells become drug-sensitive when co-treated with HA oligosaccharides. Overall, these observations form the basis for new anticancer therapeutics.

引用

页码：249 / 252

页数：4

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