Cryo-EM structure of human ATP-citrate lyase in complex with a potent inhibitor

被引:0
作者
Wei, Jia [1 ]
Leit, Silvana [2 ]
Kuai, Jun [2 ]
Therrien, Eric [3 ]
Rafi, Salma [3 ]
Harwood, H. James, Jr. [2 ]
DeLaBarre, Byron [2 ]
Tong, Liang [1 ]
机构
[1] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA
[2] Nimbus Therapeut, 130 Prospect St,Suite 301, Cambridge, MA 02139 USA
[3] Schrodinger LLC, 120 West 45 St,17th Floor, New York, NY 10036 USA
来源
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES | 2019年 / 75卷
关键词
D O I
10.1107/S0108767319096387
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
引用
收藏
页码:A373 / A373
页数:1
相关论文
共 1 条
[1]   An allosteric mechanism for potent inhibition of human ATP-citrate lyase [J].
Wei, Jia ;
Leit, Silvana ;
Kuai, Jun ;
Therrien, Eric ;
Rafi, Salma ;
Harwood, H. James, Jr. ;
DeLaBarre, Byron ;
Tong, Liang .
NATURE, 2019, 568 (7753) :566-+