Salvileucalin B, A Novel Diterpenoid with an Unprecedented Rearranged Neoclerodane Skeleton from Salvia leucantha Cav.

被引：71

作者：

Aoyagi, Yutaka ^{[1
]}

Yamazaki, Akira ^{[1
]}

Nakatsugawa, Chihiro ^{[1
]}

Fukaya, Haruhiko ^{[1
]}

Takeya, Koichi ^{[1
]}

Kawauchi, Susumu ^{[2
]}

Izumi, Hiroshi ^{[3
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Tokyo 1920392, Japan

[2] Tokyo Inst Technol, Dept Organ & Polymer Mat, Meguro Ku, Tokyo 1528552, Japan

[3] Natl Inst Adv Ind Sci & Technol, Tsukuba, Ibaraki 3058569, Japan

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 20期

关键词：

D O I：

10.1021/ol801620u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Salvileucalin B (2), having an unprecedented rearranged neoclerodane skeleton, was isolated from the aerial parts of Salvia leucantha Cav. (Labiatae) along with salvileucalin A (1). The absolute structures were elucidated by spectroscopic analysis, X-ray crystallographic analysis, and vibrational circular dichroism. Compound 2 represents a novel neoclerodane, characterized by a tricyclo[3.2.1.0(2,7)]octane substructure incorporating the exocyclic C-20 methylene of 1. This molecule exerted cytotoxic activity against A549 and HT-29 cells with IC50 values of 5.23 and 1.88 mu g/mL, respectively.

引用

页码：4429 / 4432

页数：4

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