Study on Pharmacokinetics of Amygdalin After Oral Administration of Semen Persicae Extraction in Rat Plasma by HPLC

被引：0
|
作者：
Zhang, Zhidan [1 ]
Gao, Wenyuan [1 ]
Ma, Chaoyi [1 ]
Liu, Changxiao [2 ]
机构：
[1] Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin 300072, Peoples R China
[2] Tianjin Inst Pharmaceut Res, Tianjin 300193, Peoples R China
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2011年 / 30卷 / 06期
关键词：
Semen Persicae; Amygdalin; Pharmacokinetics; One-compartment model; ARMENIACAE SEMEN; PRUNUS-ARMENIACA; BITTER; DEGRADATION; L;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Semen Persicae was a traditional Chinese medicine for the treatment of diseases such as inflammation and hyperlipemia. Amygdalin was one of the main active ingredients of this traditional Chinese medicine. In this paper, pharmacokinetic study was conducted to obtain pharmacokinetic parameters of amygadalin after oral administration of Semen Persicae extraction in rat plasma. HPLC-UV was used to determine the concentration of amygdalin in rat plasma at different time points after administration. The main pharmacokinetic parameters of amygdalin in rat were obtained based on the analysis of the plasma sample. The pharmacokinetics of amygdalin was fitted with a one-compartment model and it eliminated relative slowly in rats.
引用
收藏
页码：1221 / 1225
页数：5
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