Use of Letermovir as Salvage Therapy for Drug-Resistant Cytomegalovirus Retinitis

被引：79

作者：

Turner, Nicholas ^{[1
,2
]}

Strand, Andrew ^{[1
,3
]}

Grewal, Dilraj S. ^{[4
]}

Cox, Gary ^{[1
]}

Arif, Sana ^{[1
]}

Baker, Arthur W. ^{[1
,2
]}

Maziarz, Eileen K. ^{[1
]}

Saullo, Jennifer H. ^{[1
]}

Wolfe, Cameron R. ^{[1
]}

机构：

[1] Duke Univ, Sch Med, Div Infect Dis, Durham, NC 27708 USA

[2] Duke Ctr Antimicrobial Stewardship & Infect Preve, Durham, NC 27708 USA

[3] Tufts Med Ctr, Div Geog Med & Infect Dis, Boston, MA 02111 USA

[4] Duke Univ, Med Ctr, Dept Ophthalmol, Durham, NC 27710 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2019年 / 63卷 / 03期

关键词：

cytomegalovirus; ganciclovir-resistant; letermovir; COMPOUND AIC246 LETERMOVIR; LUNG-TRANSPLANT RECIPIENTS; GANCICLOVIR-RESISTANT; PROPHYLAXIS; DISEASE; FOSCARNET; OUTCOMES;

D O I：

10.1128/AAC.02337-18

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Treatment options for drug-resistant cytomegalovirus (CMV) are limited. Letermovir is a novel antiviral recently approved for CMV prophylaxis following hematopoietic cell transplantation, but its efficacy in other settings is unknown. We recently used letermovir for salvage treatment in four solid organ transplant recipients with ganciclovir-resistant CMV retinitis. All patients improved clinically without known adverse drug events. However, three patients failed to maintain virologic suppression, including two patients who developed genotypically confirmed resistance to letermovir while on therapy.

引用

页数：6

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