A phase I, open-label, study of GSK2879552, a lysine-specific demethylase 1 (LSD1) inhibitor, in patients with relapsed/refractory small cell lung carcinoma (SCLC)

被引：1

作者：

Moreno, V. ^{[1
]}

Bauer, T. M. ^{[2
]}

Infante, J. ^{[3
]}

Govindan, R. ^{[4
]}

Besse, B. ^{[5
]}

Bertino, E. ^{[6
]}

Martinez Marti, A. ^{[7
]}

Piontek, T. ^{[8
]}

Dhar, A. ^{[9
]}

机构：

[1] Fdn Jimenez Diaz Hosp, START Madrid FJD, Med Oncol, Madrid, Spain

[2] Tennessee Oncol, Sarah Cannon Res Inst, Drug Dev Unit, Nashville, TN USA

[3] Sarah Cannon Res Inst, Other, Nashville, TN USA

[4] Washington Univ, Sch Med, Med Oncol, St Louis, MO USA

[5] Inst Gustave Roussy, Dept Med, Villejuif, France

[6] Ohio State Univ, Med Ctr, Dept Internal Med, Div Med Oncol, Columbus, OH 43210 USA

[7] Vall dHebron Univ Hosp, Inst Oncol, Med Oncol, Barcelona, Spain

[8] GlaxoSmithKline, RD Projects Clin Platforms & Sci, Collegeville, PA USA

[9] GlaxoSmithKline, Onocolgy R&D, Collegeville, PA USA

来源：

ANNALS OF ONCOLOGY | 2016年 / 27卷

关键词：

D O I：

10.1093/annonc/mdw368.24

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

381P

引用

页数：1

共 50 条

[31] An open-label Phase II trial of the Plk1 inhibitor BI 2536, in patients with sensitive relapse small cell lung cancer [J].

Chu, Quincy ;

Gandhi, Leena ;

Stephenson, Joe ;

Johnson, Bruce E. ;

Govindan, Rawasmamy ;

Bradford, Daniel ;

Bonomi, Phil ;

Ellison, David ;

Eaton, Keith ;

Fritsch, Holger ;

Munzert, Gerd ;

Socinski, Mark .

JOURNAL OF THORACIC ONCOLOGY, 2009, 4 (09) :S811-S812

[32] An open-label phase 1b study of obinutuzumab plus lenalidomide in relapsed/refractory follicular B-cell lymphoma [J].

Morschhauser, Franck ;

Salles, Gilles ;

Le Gouill, Steven ;

Tilly, Herve ;

Thieblemont, Catherine ;

Bouabdallah, Krimo ;

Fabiani, Bettina ;

Menard, Cedric ;

Tarte, Karin ;

Cartron, Guillaume ;

Houot, Roch .

BLOOD, 2018, 132 (14) :1486-1494

[33] Talicabtagene autoleucel for relapsed or refractory B-cell malignancies: results from an open-label, multicentre, phase 1/2 study [J].

Jain, Hasmukh ;

Karulkar, Atharva ;

Kalra, Devanshi ;

Ravikumar, Smrithi ;

Shah, Shreshtha ;

Firfiray, Afrin ;

Pendhari, Juber ;

Jaiswal, Ankesh Kumar ;

Khan, Aalia ;

Sundharam, Manivasagam ;

Vaibhaw, Anand ;

Saroha, Ashish ;

Rajyopadhye, Shreewardhan ;

Basu, Moumita ;

Asija, Sweety ;

Chowdhury, Ambalika ;

Beher, Rohit ;

Banik, Ankit ;

Dwivedi, Alka ;

Purwar, Shalini ;

Narula, Gaurav ;

Banavali, Shripad ;

Jain, Nitin ;

Highfill, Steven L. ;

Stroncek, David ;

Fry, Terry ;

Melinkeri, Sameer ;

Wilson, Lovin ;

Agarwal, Narendra ;

Aribandi, Anil ;

Boyella, Pavan Kumar ;

Shah, Nirali N. ;

Neelapu, Sattva S. ;

Sengar, Manju ;

Purwar, Rahul .

LANCET HAEMATOLOGY, 2025, 12 (04) :e282-e293

[34] Safety and activity of talquetamab in patients with relapsed or refractory multiple myeloma (MonumenTAL-1): a multicentre, open-label, phase 1-2 study [J].

Chari, Ajai ;

Touzeau, Cyrille ;

Schinke, Carolina ;

Minnema, Monique C. ;

Berdeja, Jesus G. ;

Oriol, Albert ;

van de Donk, Niels W. C. J. ;

Rodriguez-Otero, Paula ;

Morillo, Daniel ;

Martinez-Chamorro, Carmen ;

Mateos, Maria-Victoria ;

Costa, Luciano J. ;

Caers, Jo ;

Rasche, Leo ;

Krishnan, Amrita ;

Ye, Jing Christine ;

Karlin, Lionel ;

Lipe, Brea ;

Vishwamitra, Deeksha ;

Skerget, Sheri ;

Verona, Raluca ;

Ma, Xuewen ;

Qin, Xiang ;

Ludlage, Hein ;

Campagna, Michela ;

Masterson, Tara ;

Hilder, Brandi ;

Tolbert, Jaszianne ;

Renaud, Thomas ;

Goldberg, Jenna ;

Kane, Colleen ;

Heuck, Christoph ;

San-Miguel, Jesus ;

Moreau, Philippe .

LANCET HAEMATOLOGY, 2025, 12 (04) :e269-e281

[35] A Phase 1b, Open-Label Study of Eftozanermin Alfa in Combination with Bortezomib and Dexamethasone in Patients with Relapsed or Refractory Multiple Myeloma [J].

Richardson, Paul G. ;

Polepally, Akshanth R. ;

Motwani, Monica ;

Mu, Yunming ;

Salman, Zeena ;

Penugonda, Sudhir ;

Moreau, Philippe .

BLOOD, 2020, 136

[36] Bortezomib, melphalan, and prednisone in elderly relapsed/refractory multiple myeloma patients: update of multicenter, open-label Phase 1/2 study [J].

Grammatico, Sara ;

Bringhen, Sara ;

Vozella, Federico ;

Siniscalchi, Agostina ;

Boccadoro, Mario ;

Petrucci, Maria Teresa .

LEUKEMIA & LYMPHOMA, 2017, 58 (11) :2738-2740

[37] Subcutaneous daratumumab in Chinese patients with relapsed or refractory multiple myeloma: an open-label, multicenter, phase 1 study (MMY1010) [J].

An, Gang ;

Ge, Zheng ;

Jing, Hongmei ;

Liu, Jing ;

Yang, Guoping ;

Feng, Ru ;

Xu, Zhongyuan ;

Qi, Ming ;

Wang, Jianping ;

Song, Juanjuan ;

Zhou, Wei ;

Sun, Binbin ;

Zhu, Dian ;

Chen, Xi ;

Cui, Canchan ;

Qiu, Lugui .

BLOOD SCIENCE, 2024, 6 (03) :e00193

[38] A phase 1 study of ABT-263 in patients with relapsed small cell lung cancer (SCLC) and other solid tumors [J].

Gandhi, Leena ;

Camidge, David R. ;

de Oliveira, Moacyr R. ;

Bonomi, Philip D. ;

Gandara, David ;

Chiu Yi-Lin ;

Xiong, Hao ;

Enschede, Sari H. ;

Krivoshik, Andrew P. ;

Rudin, Charles M. .

JOURNAL OF THORACIC ONCOLOGY, 2009, 4 (09) :S394-S394

[39] EZH2 inhibitor tazemetostat in patients with relapsed or refractory, BAP1-inactivated malignant pleural mesothelioma: a multicentre, open-label, phase 2 study [J].

Zauderer, Marjorie G. ;

Szlosarek, Peter W. ;

Le Moulec, Sylvestre ;

Popat, Sanjay ;

Taylor, Paul ;

Planchard, David ;

Scherpereel, Arnaud ;

Koczywas, Marianna ;

Forster, Martin ;

Cameron, Robert B. ;

Peikert, Tobias ;

Michaud, Neil R. ;

Szanto, Attila ;

Yang, Jay ;

Chen, Yingxue ;

Kansra, Vikram ;

Agarwal, Shefali ;

Fennell, Dean A. .

LANCET ONCOLOGY, 2022, 23 (06) :758-767

[40] Safety, Phamacokinetics (PK), Pharmacodynamics (PD) and Preliminary Activity in Acute Leukemia of Ory-1001, a First-in-Class Inhibitor of Lysine-Specific Histone Demethylase 1A (LSD1/KDM1A): Initial Results from a First-in-Human Phase 1 Study [J].

Somervaille, Tim ;

Salamero, Olga ;

Montesinos, Pau ;

Willekens, Christophe ;

Simon, Jose Antonio Perez ;

Pigneux, Arnaud ;

Recher, Christian ;

Popat, Rakesh ;

Molinero, Cesar ;

Mascaro, Christina ;

Maes, Tamara ;

Bosch, Francesc .

BLOOD, 2016, 128 (22)

← 1 2 3 4 5 →