A phase I, open-label, study of GSK2879552, a lysine-specific demethylase 1 (LSD1) inhibitor, in patients with relapsed/refractory small cell lung carcinoma (SCLC)

被引：1

作者：

Moreno, V. ^{[1
]}

Bauer, T. M. ^{[2
]}

Infante, J. ^{[3
]}

Govindan, R. ^{[4
]}

Besse, B. ^{[5
]}

Bertino, E. ^{[6
]}

Martinez Marti, A. ^{[7
]}

Piontek, T. ^{[8
]}

Dhar, A. ^{[9
]}

机构：

[1] Fdn Jimenez Diaz Hosp, START Madrid FJD, Med Oncol, Madrid, Spain

[2] Tennessee Oncol, Sarah Cannon Res Inst, Drug Dev Unit, Nashville, TN USA

[3] Sarah Cannon Res Inst, Other, Nashville, TN USA

[4] Washington Univ, Sch Med, Med Oncol, St Louis, MO USA

[5] Inst Gustave Roussy, Dept Med, Villejuif, France

[6] Ohio State Univ, Med Ctr, Dept Internal Med, Div Med Oncol, Columbus, OH 43210 USA

[7] Vall dHebron Univ Hosp, Inst Oncol, Med Oncol, Barcelona, Spain

[8] GlaxoSmithKline, RD Projects Clin Platforms & Sci, Collegeville, PA USA

[9] GlaxoSmithKline, Onocolgy R&D, Collegeville, PA USA

来源：

ANNALS OF ONCOLOGY | 2016年 / 27卷

关键词：

D O I：

10.1093/annonc/mdw368.24

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

381P

引用

页数：1

共 50 条

[21] A Phase 1/2A Open-Label Study of Pralatrexate and Gemcitabine in Patients with Relapsed or Refractory Lympboprolifierative Malignancies [J].

Horwitz, Steven M. ;

Vose, Julie M. ;

Advani, Ranjana ;

Sankhala, Kamalesh ;

Padmanabhan, Swaminathan ;

Hamlin, Paul A., Jr. ;

Chen, Andy ;

Wilroy, Shannon ;

Zain, Jasmine M. ;

Wright, Danielle ;

Weissbrot, Hanna ;

Hohenstein, Maribeth ;

Cagnoni, Pablo J. ;

Saunders, Michael E. ;

O'Connor, Owen A. .

BLOOD, 2008, 112 (11) :557-557

[22] Clinical profile of gilteritinib in Japanese patients with relapsed/refractory acute myeloid leukemia: An open-label phase 1 study [J].

Usuki, Kensuke ;

Sakura, Toru ;

Kobayashi, Yukio ;

Miyamoto, Toshihiro ;

Iida, Hiroatsu ;

Morita, Satoshi ;

Bahceci, Erkut ;

Kaneko, Masahito ;

Kusano, Mikiko ;

Yamada, Shunsuke ;

Takeshita, Shigeru ;

Miyawaki, Shuichi ;

Naoe, Tomoki .

CANCER SCIENCE, 2018, 109 (10) :3235-3244

[23] Phase 1, Open-Label, Dose Escalation Study of I-131-CLR1404 in Patients with Relapsed or Refractory Multiple Myeloma (RRMM) [J].

Ailawadhi, Sikander ;

Stiff, Patrick J. ;

Maharaj, Michele ;

Oliver, Katherine ;

Callander, Natalie Scott .

BLOOD, 2016, 128 (22)

[24] An open label phase II trial of the Plk1 inhibitor BI 2536, in patients with sensitive relapse small cell lung cancer (SCLC) [J].

Gandhi, L. ;

Chu, Q. S. ;

Stephenson, J. ;

Johnson, B. E. ;

Govindan, R. ;

Bonomi, P. ;

Eaton, K. ;

Fritsch, H. ;

Munzert, G. ;

Socinski, M. .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (15)

[25] The Plk1 inhibitor BI 2536 in patients with refractory or relapsed non-Hodgkin lymphoma: a phase I, open-label, single dose-escalation study [J].

Vose, Julie M. ;

Friedberg, Jonathan W. ;

Waller, Edmund K. ;

Cheson, Bruce D. ;

Juvvigunta, Vasthala ;

Fritsch, Holger ;

Petit, Claude ;

Munzert, Gerd ;

Younes, Anas .

LEUKEMIA & LYMPHOMA, 2013, 54 (04) :708-713

[26] SC-002 in patients with relapsed or refractory small cell lung cancer and large cell neuroendocrine carcinoma: Phase 1 study [J].

Morgensztern, Daniel ;

Johnson, Melissa ;

Rudin, Charles M. ;

Rossi, Michael ;

Lazarov, Mirella ;

Brickman, Daniel ;

Fong, Abraham .

LUNG CANCER, 2020, 145 :126-131

[27] RESILIENT part 2: A randomized, open-label phase III study of liposomal irinotecan versus topotecan in adults with relapsed small cell lung cancer (SCLC) [J].

Rudin, C. M. ;

Dowlati, A. ;

Chen, Y. ;

Navarro Mendivil, A. F. ;

Yang, J. C-H. ;

Stojanovic, G. ;

Rich, P. ;

Andric, Z. G. ;

Wu, Y-L. ;

Chen, H. ;

Zhang, L. ;

Yeung, S. ;

Benzaghou, F. M. ;

Paz-Ares, L. ;

Bunn, P. A. .

JOURNAL OF THORACIC ONCOLOGY, 2023, 18 (04) :S129-S130

[28] A Phase I dose escalation and expansion study of seclidemstat (SP-2577) a first-in class reversible LSD1 inhibitor for patients with relapsed or refractory Ewing sarcoma [J].

Reed, Damon ;

DuBois, Steven G. ;

Gorlick, Richard ;

Mascarenhas, Leo ;

Harrison, Douglas ;

Metts, Jonathan ;

Lessnick, Stephen L. ;

Crompton, Brian D. ;

Loeb, David M. ;

Hernandez, Rose ;

Larson, Jeff ;

Stenehjem, David D. .

CANCER RESEARCH, 2019, 79 (13)

[29] Phase 1, Open-Label, Dose Escalation Study of I-131-CLR1404 (CLR 131) in Patients with Relapsed or Refractory Multiple Myeloma [J].

Longcor, Jarrod ;

Oliver, Kate .

BLOOD, 2019, 134

[30] A phase 1, open-label, dose-escalation study of pralatrexate incombination with bortezomib in patients with relapsed/refractory multiple myeloma [J].

Dunn, Tamara J. ;

Dinner, Shira ;

Price, Elizabeth ;

Coutre, Steven E. ;

Gotlib, Jason ;

Hao, Ying ;

Berube, Caroline ;

Medeiros, Bruno C. ;

Liedtke, Michaela .

BRITISH JOURNAL OF HAEMATOLOGY, 2016, 173 (02) :253-259

← 1 2 3 4 5 →