iRGD-conjugated DSPE-PEG2000 nanomicelles for targeted delivery of salinomycin for treatment of both liver cancer cells and cancer stem cells

被引：58
作者：
Mao, Xiaoli [1 ,2 ]
Liu, Junjie [1 ]
Gong, Zhirong [1 ]
Zhang, He [1 ]
Lu, Ying [1 ,2 ]
Zou, Hao [1 ]
Yu, Yuan [1 ]
Chen, Yan [1 ]
Sun, Zhiguo [1 ]
Li, Wei [3 ]
Li, Bohua [3 ]
Gao, Jie [1 ]
Zhong, Yanqiang [1 ,2 ]
机构：
[1] Second Mil Med Univ, Sch Pharm, Dept Pharmaceut Sci, Shanghai 200433, Peoples R China
[2] Fujian Univ Tradit Chinese Med, Sch Pharm, Fujian, Peoples R China
[3] Second Mil Med Univ, Int Joint Canc Inst, Shanghai 200433, Peoples R China
来源：
NANOMEDICINE | 2015年 / 10卷 / 17期
基金：
中国国家自然科学基金;
关键词：
cancer nanotechnology; cancer stem cells; iRGD; liver cancer; micelles; TUMOR-INITIATING CELLS; IN-VITRO PROPAGATION; BREAST-CANCER; HEPATOCELLULAR-CARCINOMA; LOADED NANOPARTICLES; DRUG-DELIVERY; MICELLES; INTEGRINS; ACCUMULATION; EQUILIBRIUM;
D O I：
10.2217/nnm.15.106
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aims: To develop novel iRGD (internalizing Arg-Gly-Asp peptide)-conjugated DSPE-PEG2000 nanomicelles (M-SAL-iRGD) for delivery of salinomycin to both liver cancer cells and cancer stem cells (CSCs). Materials & methods: The characterization, antitumor activity and mechanism of action of M-SAL-iRGD were evaluated. Results & conclusion: M-SAL-iRGD possessed a small size of around 10 nm, and drug encapsulation efficacy higher than 90%. M-SAL-iRGD showed significantly increased cytotoxic effect toward both nontargeted M-SAL (salinomycin-loaded DSPE-PEG2000 nanomicelles) and salinomycin in both liver cancer cells and CSCs. The tissue distribution and antitumor assays in mice bearing liver cancer xenograft confirmed the superior penetration tumor efficacy and antitumor activity of M-SAL-iRGD. M-SAL-iRGD represent a potential effective nanomedicine against liver cancer.
引用
收藏
页码：2677 / 2695
页数：19
相关论文
共 61 条
[1]  
Arleth L, 2014, J PHARM SCI, V93, P2476
[2]   Herceptin-decorated Salinomycin-loaded nanoparticles for breast tumor targeting [J].
Aydin, R. Seda Tigli .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2013, 101 (05) :1405-1415
[3]   Targeted drug delivery to tumors: Myths, reality and possibility [J].
Bae, You Han ;
Park, Kinam .
JOURNAL OF CONTROLLED RELEASE, 2011, 153 (03) :198-205
[4]   Cancer Stem Cell Niche: The Place to Be [J].
Borovski, Tijana ;
Melo, Felipe De Sousa E. ;
Vermeulen, Louis ;
Medema, Jan Paul .
CANCER RESEARCH, 2011, 71 (03) :634-639
[5]  
Cabral H, 2011, NAT NANOTECHNOL, V6, P815, DOI [10.1038/NNANO.2011.166, 10.1038/nnano.2011.166]
[6]   Sphere-forming cell subpopulations with cancer stem cell properties in human hepatoma cell lines [J].
Cao, Lu ;
Zhou, Yanming ;
Zhai, Beibei ;
Liao, Jian ;
Xu, Wen ;
Zhang, Ruixiu ;
Li, Jing ;
Zhang, Yu ;
Chen, Lei ;
Qian, Haihua ;
Wu, Mengchao ;
Yin, Zhengfeng .
BMC GASTROENTEROLOGY, 2011, 11
[7]   Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state [J].
Chaffer, Christine L. ;
Brueckmann, Ines ;
Scheel, Christina ;
Kaestli, Alicia J. ;
Wiggins, Paul A. ;
Rodrigues, Leonardo O. ;
Brooks, Mary ;
Reinhardt, Ferenc ;
Su, Ying ;
Polyak, Kornelia ;
Arendt, Lisa M. ;
Kuperwasser, Charlotte ;
Bierie, Brian ;
Weinberg, Robert A. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (19) :7950-7955
[8]   Integrins in cancer: biological implications and therapeutic opportunities [J].
Desgrosellier, Jay S. ;
Cheresh, David A. .
NATURE REVIEWS CANCER, 2010, 10 (01) :9-22
[9]   Use of nanoscale delivery systems to maintain synergistic drug ratios in vivo [J].
Dicko, Awa ;
Mayer, Lawrence D. ;
Tardi, Paul G. .
EXPERT OPINION ON DRUG DELIVERY, 2010, 7 (12) :1329-1341
[10]   In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells [J].
Dontu, G ;
Abdallah, WM ;
Foley, JM ;
Jackson, KW ;
Clarke, MF ;
Kawamura, MJ ;
Wicha, MS .
GENES & DEVELOPMENT, 2003, 17 (10) :1253-1270
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